Abstract：
A study was carried out to demonstrate the effects of chloroquine on liver of developing albino rats. In this study, 20 white albino mice were used, and distributed in 2 groups. They were kept in the animal house of the College of Veterinary Medicine, their ages ranged between (4-3) months and they were in good health. The first group (G1) was considered a control group, this group included 10 mice who were given regular food in addition to sterilized water daily for a period of (30) days, the second group (G2) included 10 mice, they were given food and water with chloroquine after mixing it in 1ml of distilled water at a dose of 1.2 mg/kg/day for each animal orally for a period of 30 days, it was found that chloroquine induced toxicity in liver tissue of albino mice which were exposed to chloroquine drug for longer during their life. Histological sections of stomach revealed that degenerative cases were present in the mucosa of it and the gastric glands also demonstrated sloughing of its mucus cells, and histological sections of small intestine indicated that the degenerative changes were present in the mucosa and submucosa reflected by sloughing of certain villi and the intestinal glands were also affected, lymphocytic infiltration was present in between the intestinal glands with plasma cells. The present study indicated that the liver tissue was affected by drug used via effect on the histological structure, as there was hypertrophy and degeneration of liver cells, hypertrophy of Kupffer cells in the blood sinusoids.
摘要：
进行了一项研究以证明氯喹对发育中的白化病大鼠肝脏的影响。在这项研究中,使用了20只白色白化病小鼠，并分布在2组。它们被关在兽医学院的动物屋里，他们的年龄介于（4-3）个月之间，身体健康。第一组（G1）被认为是对照组，该组包括10只小鼠，每天除了无菌水之外，还给予常规食物，持续（30）天，第二组（G2）包括10只小鼠，在每只动物以1.2mg/kg/天的剂量在1ml蒸馏水中混合后，给予它们与氯喹的食物和水，口服30天，研究发现，氯喹对长期接触氯喹药物的白化病小鼠的肝组织产生毒性。胃的组织学切片显示，粘膜中存在变性病例，胃腺也显示其粘液细胞脱落，小肠的组织学切片表明，某些绒毛脱落反映的粘膜和粘膜下层存在退行性变化，肠腺也受到影响，肠腺与浆细胞之间存在淋巴细胞浸润。本研究表明，肝组织受到药物通过对组织学结构的影响而受到影响，因为肝细胞肥大和退化，血窦中Kupffer细胞肥大。
