Abstract：
Diabetes mellitus is a metabolic disorder characterized by high blood sugar levels. In recent years, T2DM has become a worldwide health issue due to an increase in incidence and prevalence. Diabetic kidney disease (DKD) is one of the devastating consequences of diabetes, especially owing to T2DM and the key clinical manifestation of DKD is weakened renal function and progressive proteinuria. DKD affects approximately 1/3rd of patients with diabetes mellitus, and T2DM is the predominant cause of end-stage kidney disease (ESKD). Several lines of studies have observed the association between vitamin D deficiency and the progression and etiology of type II diabetes mellitus. Emerging experimental evidence has shown that T2DM is associated with various kinds of kidney diseases. Recent evidence has also shown that an alteration in VDR (vitamin D receptor) signaling in podocytes leads to DKD. The present review aims to examine vitamin D metabolism and its correlation with T2DM. Furthermore, we discuss the potential role of vitamin D and VDR in diabetic kidney disease.
摘要：
糖尿病是一种以高血糖为特征的代谢紊乱。近年来,由于发病率和患病率的增加，T2DM已成为世界性的健康问题。糖尿病肾病（DKD）是糖尿病的毁灭性后果之一，尤其是由于2型糖尿病，DKD的主要临床表现是肾功能减弱和进行性蛋白尿。DKD影响约1/3的糖尿病患者，T2DM是终末期肾病（ESKD）的主要病因。一些研究已经观察到维生素D缺乏与II型糖尿病的进展和病因之间的关联。新兴的实验证据表明，T2DM与各种肾脏疾病有关。最近的证据还表明,足细胞中VDR(维生素D受体)信号的改变导致DKD。本综述旨在探讨维生素D代谢及其与T2DM的相关性。此外，我们讨论了维生素D和VDR在糖尿病肾病中的潜在作用。
