Abstract：
The mitochondria‑associated endoplasmic reticulum (ER) membrane (MAM), serving as a vital link between the mitochondria and ER, holds a pivotal role in maintaining the physiological function of these two organelles. Its specific functions encompass the participation in the biosynthesis and functional regulation of the mitochondria, calcium ion transport, lipid metabolism, oxidative stress and autophagy among numerous other facets. Scientific exploration has revealed that MAMs hold potential as effective therapeutic targets influencing the mitochondria and ER within the context of cancer therapy. The present review focused on elucidating the related pathways of mitochondrial autophagy and ER stress and their practical application in ovarian cancer, aiming to identify commonalities existing between MAMs and these pathways, thereby extending to related applications of MAMs in ovarian cancer treatment. This endeavor aimed at exploring new potential for MAMs in clinically managing ovarian cancer.
摘要：
线粒体相关内质网（ER）膜（MAM），作为线粒体和内质网之间的重要纽带，在维持这两种细胞器的生理功能方面起着关键作用。其特定功能包括参与线粒体的生物合成和功能调节，钙离子运输，脂质代谢，氧化应激和自噬在许多其他方面。科学探索表明，MAM在癌症治疗的背景下具有作为影响线粒体和ER的有效治疗靶标的潜力。本文就线粒体自噬与内质网应激的相关通路及其在卵巢癌中的应用作一综述。旨在确定MAM和这些途径之间存在的共性，从而扩展MAMs在卵巢癌治疗中的相关应用。这项努力旨在探索MAM在临床治疗卵巢癌中的新潜力。
