Abstract：
FOXM1 is a key transcriptional regulator involved in various biological processes in mammals, including carbohydrate and lipid metabolism, aging, immune regulation, development, and disease. Early studies have shown that FOXM1 acts as an oncogene by regulating cell proliferation, cell cycle, migration, metastasis, and apoptosis, as well as genes related to diagnosis, treatment, chemotherapy resistance, and prognosis. Researchers are increasingly focusing on FOXM1 functions in tumor microenvironment, epigenetics, and immune infiltration. However, researchers have not comprehensively described FOXM1\'s involvement in tumor microenvironment shaping, epigenetics, and immune cell infiltration. Here we review the role of FOXM1 in the formation and development of malignant tumors, and we will provide a comprehensive summary of the role of FOXM1 in transcriptional regulation, interacting proteins, tumor microenvironment, epigenetics, and immune infiltration, and suggest areas for further research.
摘要：
FOXM1是参与哺乳动物各种生物过程的关键转录调节因子,包括碳水化合物和脂质代谢，老化，免疫调节，发展,和疾病。早期研究表明，FOXM1作为癌基因通过调节细胞增殖，细胞周期,迁移,转移,和细胞凋亡，以及与诊断相关的基因，治疗,化疗耐药,和预后。研究人员越来越关注FOXM1在肿瘤微环境中的功能，表观遗传学,和免疫浸润。然而,研究人员尚未全面描述FOXM1参与肿瘤微环境塑造，表观遗传学,和免疫细胞浸润。本文就FOXM1在恶性肿瘤形成和发展中的作用作一综述。我们将全面总结FOXM1在转录调控中的作用，相互作用的蛋白质，肿瘤微环境,表观遗传学,和免疫浸润，并提出了进一步研究的领域。
