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Abstract：
Esophageal squamous cell carcinoma (ESCC) is a prevalent and deadly malignancy of the digestive tract. Recent research has identified long non‑coding RNAs (lncRNAs) as crucial regulators in the pathogenesis of ESCC. These lncRNAs, typically exceeding 200 nucleotides, modulate gene expression through various mechanisms, including the competing endogenous RNA (ceRNA) pathway and RNA‑protein interactions. The current study reviews the multifaceted roles of lncRNAs in ESCC, highlighting their involvement in processes such as proliferation, migration, invasion, epithelial‑mesenchymal transition, cell cycle progression, resistance to radiotherapy and chemotherapy, glycolysis, apoptosis, angiogenesis, autophagy, tumor growth, metastasis and the maintenance of cancer stem cells. Specific lncRNAs like HLA complex P5, LINC00963 and non‑coding repressor of NFAT have been shown to enhance resistance to radio‑ and chemotherapy by modulating pathways such as AKT signaling and microRNA interaction, which promote cell survival and proliferation under therapeutic stress. Furthermore, lncRNAs like family with sequence similarity 83, member A antisense RNA 1, zinc finger NFX1‑type containing 1 antisense RNA 1 and taurine upregulated gene 1 are implicated in enhancing invasive and proliferative capabilities of ESCC cells through the ceRNA mechanism, while interactions with RNA‑binding proteins further influence cancer cell behavior. The comprehensive analysis underscores the potential of lncRNAs as biomarkers for prognosis and therapeutic targets in ESCC, suggesting avenues for future research focused on elucidating the detailed molecular mechanisms and clinical applications of lncRNAs in ESCC management.
摘要：
食管鳞状细胞癌（ESCC）是一种常见且致命的消化道恶性肿瘤。最近的研究已经确定长链非编码RNA（lncRNAs）是ESCC发病机制中的关键调节因子。这些lncRNAs，通常超过200个核苷酸，通过各种机制调节基因表达，包括竞争性内源性RNA(ceRNA)途径和RNA-蛋白质相互作用。本研究回顾了lncRNAs在ESCC中的多方面作用，强调他们参与扩散等过程，迁移,入侵,上皮间质转化，细胞周期进程，对放疗和化疗的抵抗力，糖酵解,凋亡，血管生成,自噬,肿瘤生长，转移和癌症干细胞的维持。特定的lncRNAs，如HLA复合物P5，LINC00963和NFAT的非编码阻遏物，已被证明可以通过调节AKT信号传导和microRNA相互作用等途径来增强对放疗和化疗的抵抗力。在治疗应激下促进细胞存活和增殖。此外，具有序列相似性的lncRNAs样家族83、成员A反义RNA1、含有1个反义RNA1和牛磺酸上调基因1的锌指NFX1型与通过ceRNA机制增强ESCC细胞的侵袭和增殖能力有关，而与RNA结合蛋白的相互作用进一步影响癌细胞的行为。综合分析强调了lncRNAs作为ESCC预后和治疗靶点的生物标志物的潜力，建议未来研究的途径集中于阐明lncRNAs在ESCC管理中的详细分子机制和临床应用。
