Abstract：
Ayahuasca, a psychoactive beverage native to the Amazon, originally derived from Banisteriopsis caapi stem scrapings and Psychotria viridis leaves, exhibits hallucinogenic properties due to N,N-dimethyltryptamine. When combined with β-carbolines, it enters the bloodstream and central nervous system, inhibiting monoamine oxidase-A. Over time, therapeutic effects have been associated to ayahuasca consumption. This study assessed the impact of extracts from three plant decoctions used in ayahuasca preparation on the gastric adenocarcinoma cell line (AGS). MTT reduction assays selected B. caapi, Mimosa hostilis, and Peganum harmala samples as most effective. Lactate dehydrogenase activity evaluated membrane integrity loss, while oxidative stress induction was measured using dihydroethidium and 2\',7\'-dichlorodihydrofluorescein diacetate probes. Results revealed apoptosis induction in AGS cells, with all three samples significantly reducing oxidative stress.
摘要：
Ayahuasca,一种原产于亚马逊的精神活性饮料，最初来自于Banisteriopsiscaapi茎屑和Psychotriaviridis叶，由于N，表现出致幻特性，N-二甲基色胺.当与β-咔啉类联用时，它进入血液和中枢神经系统，抑制单胺氧化酶-A。随着时间的推移,治疗效果与ayahuasca的消费有关。这项研究评估了ayahuasca制剂中使用的三种植物汤的提取物对胃腺癌细胞系（AGS）的影响。MTT还原试验选择B.caapi，含羞草敌意，和harmala的样本是最有效的。乳酸脱氢酶活性评估膜完整性损失，而氧化应激诱导是使用二氢乙锭和2'测量的，7'-二氯二氢荧光素二乙酸探针。结果显示AGS细胞凋亡诱导，所有三个样品均显着降低了氧化应激。
