Abstract：
BACKGROUND: Amyloid positron emission tomography (PET) acquisition timing impacts quantification.
METHODS: In florbetaben (FBB) PET scans of 245 adults with and without cognitive impairment, we investigated the impact of post-injection acquisition time on Centiloids (CLs) across five reference regions. CL equations for FBB were derived using standard methods, using FBB data collected between 90 and 110 min with paired Pittsburgh compound B data. Linear mixed models and t-tests evaluated the impact of acquisition time on CL increases.
RESULTS: CL values increased significantly over the scan using the whole cerebellum, cerebellar gray matter, and brainstem as reference regions, particularly in amyloid-positive individuals. In contrast, CLs based on white matter-containing reference regions decreased across the scan.
CONCLUSIONS: The quantification of CLs in FBB PET imaging is influenced by both the overall scan acquisition time and the choice of reference region. Standardized acquisition protocols or the application of acquisition time-specific CL equations should be implemented in clinical protocols.
CONCLUSIONS: Acquisition timing affects florbetaben positron emission tomography (PET) scan quantification, especially in amyloid-positive participants. The impact of acquisition timing on quantification varies across common reference regions. Consistent acquisitions and/or appropriate post-injection adjustments are needed to ensure comparability of PET data.
METHODS: In florbetaben (FBB) PET scans of 245 adults with and without cognitive impairment, we investigated the impact of post-injection acquisition time on Centiloids (CLs) across five reference regions. CL equations for FBB were derived using standard methods, using FBB data collected between 90 and 110 min with paired Pittsburgh compound B data. Linear mixed models and t-tests evaluated the impact of acquisition time on CL increases.
RESULTS: CL values increased significantly over the scan using the whole cerebellum, cerebellar gray matter, and brainstem as reference regions, particularly in amyloid-positive individuals. In contrast, CLs based on white matter-containing reference regions decreased across the scan.
CONCLUSIONS: The quantification of CLs in FBB PET imaging is influenced by both the overall scan acquisition time and the choice of reference region. Standardized acquisition protocols or the application of acquisition time-specific CL equations should be implemented in clinical protocols.
CONCLUSIONS: Acquisition timing affects florbetaben positron emission tomography (PET) scan quantification, especially in amyloid-positive participants. The impact of acquisition timing on quantification varies across common reference regions. Consistent acquisitions and/or appropriate post-injection adjustments are needed to ensure comparability of PET data.
摘要：
背景：淀粉样蛋白正电子发射断层扫描（PET）采集定时影响定量。
方法：在245例有和没有认知障碍的成年人的florbetaben（FBB）PET扫描中，我们调查了注射后采集时间对五个参考区域中的Centiloids（CLs）的影响。使用标准方法推导了FBB的CL方程，使用90至110分钟之间收集的FBB数据与配对的匹兹堡化合物B数据。线性混合模型和t检验评估了采集时间对CL增加的影响。
结果：使用整个小脑进行扫描时，CL值显著增加，小脑灰质,和脑干作为参考区域，特别是在淀粉样蛋白阳性个体中。相比之下,基于含白质参考区域的CL在整个扫描中减少。
结论：FBBPET成像中CLs的定量受整体扫描采集时间和参考区域选择的影响。应在临床协议中实施标准化的采集协议或采集时间特定的CL方程的应用。
结论：采集时间影响氟倍他本正电子发射断层扫描（PET）扫描定量，尤其是淀粉样蛋白阳性的参与者。采集定时对量化的影响在公共参考区域中变化。需要一致的采集和/或适当的注射后调整以确保PET数据的可比性。
方法：在245例有和没有认知障碍的成年人的florbetaben（FBB）PET扫描中，我们调查了注射后采集时间对五个参考区域中的Centiloids（CLs）的影响。使用标准方法推导了FBB的CL方程，使用90至110分钟之间收集的FBB数据与配对的匹兹堡化合物B数据。线性混合模型和t检验评估了采集时间对CL增加的影响。
结果：使用整个小脑进行扫描时，CL值显著增加，小脑灰质,和脑干作为参考区域，特别是在淀粉样蛋白阳性个体中。相比之下,基于含白质参考区域的CL在整个扫描中减少。
结论：FBBPET成像中CLs的定量受整体扫描采集时间和参考区域选择的影响。应在临床协议中实施标准化的采集协议或采集时间特定的CL方程的应用。
结论：采集时间影响氟倍他本正电子发射断层扫描（PET）扫描定量，尤其是淀粉样蛋白阳性的参与者。采集定时对量化的影响在公共参考区域中变化。需要一致的采集和/或适当的注射后调整以确保PET数据的可比性。
