PDF(Pubmed)
Abstract：
UNASSIGNED: Nonauditory symptoms can be a prominent feature in patients with sporadic vestibular schwannoma (VS), but the cause of these symptoms is unknown. Inflammation is hypothesized to play a key role in the growth and symptomatic presentation of sporadic VS, and in this study, we investigated through translocator protein (TSPO) positron emission tomography (PET) whether inflammation occurred within the \"normal appearing\" brain of such patients and its association with tumor growth.
UNASSIGNED: Dynamic PET datasets from 15 patients with sporadic VS (8 static and 7 growing) who had been previously imaged using the TSPO tracer [11C](R)-PK11195 were included. Parametric images of [11C](R)-PK11195 binding potential (BPND) and the distribution volume ratio (DVR) were derived and compared across VS growth groups within both contralateral and ipsilateral gray (GM) and white matter (WM) regions. Voxel-wise cluster analysis was additionally performed to identify anatomical regions of increased [11C](R)-PK11195 binding.
UNASSIGNED: Compared with static tumors, growing VS demonstrated significantly higher cortical (GM, 1.070 vs. 1.031, P = .03) and whole brain (GM & WM, 1.045 vs. 1.006, P = .03) [11C](R)-PK11195 DVR values. The voxel-wise analysis supported the region-based analysis and revealed clusters of high TSPO binding within the precentral, postcentral, and prefrontal cortex in patients with growing VS.
UNASSIGNED: We present the first in vivo evidence of increased TSPO expression and inflammation within the brains of patients with growing sporadic VS. These results provide a potential mechanistic insight into the development of nonauditory symptoms in these patients and highlight the need for further studies interrogating the role of neuroinflammation in driving VS symptomatology.
UNASSIGNED: Dynamic PET datasets from 15 patients with sporadic VS (8 static and 7 growing) who had been previously imaged using the TSPO tracer [11C](R)-PK11195 were included. Parametric images of [11C](R)-PK11195 binding potential (BPND) and the distribution volume ratio (DVR) were derived and compared across VS growth groups within both contralateral and ipsilateral gray (GM) and white matter (WM) regions. Voxel-wise cluster analysis was additionally performed to identify anatomical regions of increased [11C](R)-PK11195 binding.
UNASSIGNED: Compared with static tumors, growing VS demonstrated significantly higher cortical (GM, 1.070 vs. 1.031, P = .03) and whole brain (GM & WM, 1.045 vs. 1.006, P = .03) [11C](R)-PK11195 DVR values. The voxel-wise analysis supported the region-based analysis and revealed clusters of high TSPO binding within the precentral, postcentral, and prefrontal cortex in patients with growing VS.
UNASSIGNED: We present the first in vivo evidence of increased TSPO expression and inflammation within the brains of patients with growing sporadic VS. These results provide a potential mechanistic insight into the development of nonauditory symptoms in these patients and highlight the need for further studies interrogating the role of neuroinflammation in driving VS symptomatology.
摘要：
■非听觉症状可能是散发性前庭神经鞘瘤（VS）患者的突出特征，但这些症状的原因尚不清楚。假设炎症在零星VS的生长和症状表现中起关键作用，在这项研究中，我们通过转运蛋白（TSPO）正电子发射断层扫描（PET）研究了此类患者的“正常”脑内是否发生了炎症及其与肿瘤生长的关系。
■来自先前使用TSPO示踪剂[11C]（R）-PK11195成像的15例散发性VS（8例静态和7例生长）患者的动态PET数据集。得出[11C]（R）-PK11195结合电位（BPND）和分布体积比（DVR）的参数图像，并在对侧和同侧灰色（GM）和白质（WM）区域的VS生长组中进行比较。另外进行体素聚类分析以鉴定[11C](R)-PK11195结合增加的解剖区域。
■与静态肿瘤相比，生长的VS表现出明显更高的皮质(GM，1.070vs.1.031，P=.03）和全脑（GM和WM，1.045vs.1.006，P=.03）[11C]（R）-PK11195DVR值。逐体素分析支持基于区域的分析，并揭示了前中心内的高TSPO结合簇，postcentral,生长VS患者的前额叶皮层。
■我们提供了第一个体内证据，表明散发性VS患者大脑中TSPO表达和炎症增加。这些结果为这些患者非听觉症状的发展提供了潜在的机制见解，并强调需要进一步研究神经炎症在驱动VS症状学中的作用。
■来自先前使用TSPO示踪剂[11C]（R）-PK11195成像的15例散发性VS（8例静态和7例生长）患者的动态PET数据集。得出[11C]（R）-PK11195结合电位（BPND）和分布体积比（DVR）的参数图像，并在对侧和同侧灰色（GM）和白质（WM）区域的VS生长组中进行比较。另外进行体素聚类分析以鉴定[11C](R)-PK11195结合增加的解剖区域。
■与静态肿瘤相比，生长的VS表现出明显更高的皮质(GM，1.070vs.1.031，P=.03）和全脑（GM和WM，1.045vs.1.006，P=.03）[11C]（R）-PK11195DVR值。逐体素分析支持基于区域的分析，并揭示了前中心内的高TSPO结合簇，postcentral,生长VS患者的前额叶皮层。
■我们提供了第一个体内证据，表明散发性VS患者大脑中TSPO表达和炎症增加。这些结果为这些患者非听觉症状的发展提供了潜在的机制见解，并强调需要进一步研究神经炎症在驱动VS症状学中的作用。
