PDF(Pubmed)
Abstract：
UNASSIGNED: Previous studies have demonstrated a correlation between the ratio of alanine aminotransferase to high-density lipoprotein cholesterol (ALT/HDL-C) in the serum and the risk of diabetes. However, no existing study has investigated the association between insulin resistance (IR) and ALT/HDL-C. Therefore, this study aims to explore the association between ALT/HDL-C and IR in American adults.
UNASSIGNED: A total of 7,599 adults selected from the National Health and Nutrition Examination Survey (NHANES) in 2013 to 2020 were studied. IR was assessed based on the homeostatic model assessment of insulin resistance (HOMA-IR). And the association between IR and ALT/HDL-C was assessed through multiple logistic regression, generalized smooth curve fitting and subgroup analyses.
UNASSIGNED: Multiple logistic regression analysis indicated a significant correlation between IR and ALT/HDL-C, with odds ratios (OR) of 1.04 (95% CI = 1.02-1.05) in males and 1.04 (95% CI = 1.02-1.07) in females. A non-linear association and saturation effect between ALT/HDL-C and IR risk were identified, with an inverted L shaped curve and an inflection point at 33.62. The area under the ROC curve (AUC) of ALT/HDL-C was significantly larger (AUC = 0.725 for males and 0.696 for females, all p < 0.01) compared with the use of ALT, HDL-C, AST and AST/ALT. Subgroup analysis showed a significantly higher independent association in obese individuals and individuals aged ≥50 years (All P interaction <0.05).
UNASSIGNED: Elevated ALT/HDL-C demonstrates a significant correlation with IR, which can be used as a potential indicator of IR in American adults.
UNASSIGNED: A total of 7,599 adults selected from the National Health and Nutrition Examination Survey (NHANES) in 2013 to 2020 were studied. IR was assessed based on the homeostatic model assessment of insulin resistance (HOMA-IR). And the association between IR and ALT/HDL-C was assessed through multiple logistic regression, generalized smooth curve fitting and subgroup analyses.
UNASSIGNED: Multiple logistic regression analysis indicated a significant correlation between IR and ALT/HDL-C, with odds ratios (OR) of 1.04 (95% CI = 1.02-1.05) in males and 1.04 (95% CI = 1.02-1.07) in females. A non-linear association and saturation effect between ALT/HDL-C and IR risk were identified, with an inverted L shaped curve and an inflection point at 33.62. The area under the ROC curve (AUC) of ALT/HDL-C was significantly larger (AUC = 0.725 for males and 0.696 for females, all p < 0.01) compared with the use of ALT, HDL-C, AST and AST/ALT. Subgroup analysis showed a significantly higher independent association in obese individuals and individuals aged ≥50 years (All P interaction <0.05).
UNASSIGNED: Elevated ALT/HDL-C demonstrates a significant correlation with IR, which can be used as a potential indicator of IR in American adults.
摘要：
■先前的研究表明，血清中丙氨酸氨基转移酶与高密度脂蛋白胆固醇（ALT/HDL-C）的比例与糖尿病风险之间存在相关性。然而,目前尚无研究调查胰岛素抵抗（IR）与ALT/HDL-C之间的关联。因此,本研究旨在探讨美国成年人ALT/HDL-C与IR之间的关系。
■研究了2013年至2020年从国家健康与营养检查调查（NHANES）中选出的7,599名成年人。基于胰岛素抵抗的稳态模型评估(HOMA-IR)来评估IR。IR与ALT/HDL-C的关系通过多因素logistic回归分析,广义光滑曲线拟合和子群分析。
■多因素logistic回归分析显示IR与ALT/HDL-C有显著相关性,男性比值比（OR）为1.04（95％CI=1.02-1.05），女性为1.04（95％CI=1.02-1.07）。确定了ALT/HDL-C和IR风险之间的非线性关联和饱和效应，具有倒L形曲线和33.62处的拐点。ALT/HDL-C的ROC曲线下面积(AUC)明显较大(男性AUC=0.725,女性AUC=0.696,所有p<0.01）与使用ALT相比，HDL-C,AST和AST/ALT。亚组分析显示，肥胖个体和≥50岁个体的独立关联显著增高（所有P交互作用<0.05）。
■ALT/HDL-C升高与IR显著相关，可作为美国成年人IR的潜在指标。
■研究了2013年至2020年从国家健康与营养检查调查（NHANES）中选出的7,599名成年人。基于胰岛素抵抗的稳态模型评估(HOMA-IR)来评估IR。IR与ALT/HDL-C的关系通过多因素logistic回归分析,广义光滑曲线拟合和子群分析。
■多因素logistic回归分析显示IR与ALT/HDL-C有显著相关性,男性比值比（OR）为1.04（95％CI=1.02-1.05），女性为1.04（95％CI=1.02-1.07）。确定了ALT/HDL-C和IR风险之间的非线性关联和饱和效应，具有倒L形曲线和33.62处的拐点。ALT/HDL-C的ROC曲线下面积(AUC)明显较大(男性AUC=0.725,女性AUC=0.696,所有p<0.01）与使用ALT相比，HDL-C,AST和AST/ALT。亚组分析显示，肥胖个体和≥50岁个体的独立关联显著增高（所有P交互作用<0.05）。
■ALT/HDL-C升高与IR显著相关，可作为美国成年人IR的潜在指标。
