UNASSIGNED: In this two-sample MR study, summary statistics data of the genome-wide association studies (GWASs) on exposures, including type 1 diabetes mellitus (T1DM), T2DM, fasting glucose, and glycated hemoglobin (HbAlc), were extracted from the MRC-Integrative Epidemiology Unit (MRC-IEU). The GWAS data on study outcomes, including epilepsy, focal epilepsy, and generalized epilepsy, were obtained from the FinnGen consortium. MR-Egger regression was used to examine horizontal pleiotropism of instrumental variables (IVs), and Cochran\'s Q statistics was used to quantify the heterogeneity. MR analysis methods including inverse variance weighted (IVW) tests, weighted median, and MR-Egger were utilized to investigate the causal associations between DM and BG-related indexes with epilepsy. The evaluation indexes were odds ratios (ORs) and 95% confidence intervals (CIs). Reverse causal association analyses were also performed. In addition, IVW-radial and leave-one-out tests were utilized for sensitivity analyses.
UNASSIGNED: IVW estimates suggested that T1DM has potential causal associations with epilepsy (OR = 1.057, 95% CI: 1.031-1.084) and generalized epilepsy (OR = 1.066, 95% CI: 1.018-1.116). No significant reverse causal associations of T1DM with epilepsy or generalized epilepsy were found (all P > 0.05). In addition, sensitivity analysis results identified no outlier, indicating that the associations of T1DM with epilepsy and generalized epilepsy were relatively robust.
UNASSIGNED: Patients with T1DM had a potential risk of developing epilepsy, and prompt treatment of DM and dynamic monitoring may be beneficial to prevent epilepsy in this high-risk population. However, the causal associations of DM and BG with epilepsy may warrant further verification.
■在这项双样本MR研究中,关于暴露的全基因组关联研究(GWAS)的汇总统计数据,包括1型糖尿病(T1DM),T2DM,空腹血糖,和糖化血红蛋白(HbAlc),是从MRC综合流行病学单元(MRC-IEU)中提取的。关于研究结果的GWAS数据,包括癫痫,局灶性癫痫,和全身性癫痫,是从FinnGen财团获得的。MR-Egger回归用于检查工具变量(IVs)的水平多向性,Cochran的Q统计量被用来量化异质性。MR分析方法包括逆方差加权(IVW)检验,加权中位数,和MR-Egger用于研究DM和BG相关指标与癫痫之间的因果关系。评价指标为比值比(ORs)和95%置信区间(CIs)。还进行了反向因果关联分析。此外,IVW-径向和留一检验用于敏感性分析。
■IVW估计表明,T1DM与癫痫(OR=1.057,95%CI:1.031-1.084)和全身性癫痫(OR=1.066,95%CI:1.018-1.116)有潜在的因果关系。未发现T1DM与癫痫或全身性癫痫的反向因果关联(均P>0.05)。此外,敏感性分析结果没有发现异常值,这表明T1DM与癫痫和全身性癫痫的相关性相对稳健.
■T1DM患者有发生癫痫的潜在风险,及时治疗和动态监测可能有利于预防此高危人群的癫痫。然而,DM和BG与癫痫的因果关系可能需要进一步验证.