PDF(Pubmed)
Abstract：
UNASSIGNED: Cumulative evidence has suggested that vitamin D deficiency is related with an increased susceptibility to various types of cancers. However, the association between vitamin D and thyroid cancer (TC) has remained to be unknown. Thus, there has been an urgent need for a meta-analysis to summarize existing evidence on vitamin D levels and the risk of TC.
UNASSIGNED: This meta-analysis aimed to figure out the association between vitamin D level and the risk of TC.
UNASSIGNED: A systematic search was performed for eligible articles on the association between vitamin D and TC based on PubMed, Embase, Web of Science, Cochrane, and ClinicalTrials.gov. Outcomes were the vitamin D level of cases with TC and the incidence of vitamin D deficiency in cases with TC comparing with the controls. The effect measures included standardized mean difference (SMD), ratio of means (RoM), and odds ratio (OR). A dose-response meta-analysis was performed to assess the correlation between vitamin D level and the risk of TC. Subgroup analyses and meta-regressions were conducted to explore the source of heterogeneity. And publication bias was evaluated through Begg\'s and Egger\'s tests.
UNASSIGNED: Results of the meta-analysis revealed lower levels of vitamin D in TC cases comparing with those in control [SMD = -0.25, 95% CI: (-0.38, -0.12); RoM = 0.87, 95% CI: (0.81, 0.94)] and the levels of 1,25 (OH)D in cases with TC were also lower than controls [SMD = -0.49, 95% CI: (-0.80, -0.19); RoM = 0.90, 95% CI: (0.85, 0.96)]. And vitamin D deficiency was associated with the increased risk of TC [OR = 1.49, 95% CI: (1.23, 1.80)]. Additionally, results from the dose-response meta-analysis showed that there is a 6% increase in the risk of TC for each 10 ng/ml decrease in 25 (OH)D levels [OR = 0.94; 95% CI: (0.89, 0.99)].
UNASSIGNED: Individuals with TC had lower levels of vitamin D compared to controls, and vitamin D deficiency was correlated with an increase risk of TC.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=504417, identifier: CRD42024504417.
UNASSIGNED: This meta-analysis aimed to figure out the association between vitamin D level and the risk of TC.
UNASSIGNED: A systematic search was performed for eligible articles on the association between vitamin D and TC based on PubMed, Embase, Web of Science, Cochrane, and ClinicalTrials.gov. Outcomes were the vitamin D level of cases with TC and the incidence of vitamin D deficiency in cases with TC comparing with the controls. The effect measures included standardized mean difference (SMD), ratio of means (RoM), and odds ratio (OR). A dose-response meta-analysis was performed to assess the correlation between vitamin D level and the risk of TC. Subgroup analyses and meta-regressions were conducted to explore the source of heterogeneity. And publication bias was evaluated through Begg\'s and Egger\'s tests.
UNASSIGNED: Results of the meta-analysis revealed lower levels of vitamin D in TC cases comparing with those in control [SMD = -0.25, 95% CI: (-0.38, -0.12); RoM = 0.87, 95% CI: (0.81, 0.94)] and the levels of 1,25 (OH)D in cases with TC were also lower than controls [SMD = -0.49, 95% CI: (-0.80, -0.19); RoM = 0.90, 95% CI: (0.85, 0.96)]. And vitamin D deficiency was associated with the increased risk of TC [OR = 1.49, 95% CI: (1.23, 1.80)]. Additionally, results from the dose-response meta-analysis showed that there is a 6% increase in the risk of TC for each 10 ng/ml decrease in 25 (OH)D levels [OR = 0.94; 95% CI: (0.89, 0.99)].
UNASSIGNED: Individuals with TC had lower levels of vitamin D compared to controls, and vitamin D deficiency was correlated with an increase risk of TC.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=504417, identifier: CRD42024504417.
摘要：
■累积证据表明，维生素D缺乏与各种癌症的易感性增加有关。然而,维生素D与甲状腺癌(TC)之间的关系尚不清楚.因此，迫切需要进行荟萃分析,以总结维生素D水平和TC风险的现有证据.
■这项荟萃分析旨在找出维生素D水平与TC风险之间的关联。
■根据PubMed，Embase,WebofScience,科克伦,和ClinicalTrials.gov.结果是与对照组相比，TC患者的维生素D水平以及TC患者维生素D缺乏的发生率。效果测量包括标准化平均差(SMD)，均值比(RoM)，和比值比(OR)。进行剂量反应荟萃分析以评估维生素D水平与TC风险之间的相关性。进行亚组分析和荟萃回归以探索异质性的来源。并通过Begg\和Egger\的测试对发表偏倚进行了评估。
■荟萃分析的结果表明，与对照组相比，TC病例中的维生素D水平较低[SMD=-0.25，95％CI：（-0.38，-0.12）；RoM=0.87，95％CI：（0.81，0.94）]，TC病例中的1,25（OH）D水平也低于对照组[SMD=-0.49，95％CI=0.85：0.维生素D缺乏与TC风险增加相关[OR=1.49,95%CI:(1.23,1.80)]。此外,剂量-反应荟萃分析结果显示,25(OH)D水平每降低10ng/ml,TC风险就会增加6%[OR=0.94;95%CI:(0.89,0.99)].
■与对照组相比，TC患者的维生素D水平较低，维生素D缺乏与TC风险增加相关。
■https://www.crd.约克。AC.uk/PROSPERO/display_record。php?RecordID=504417，标识符：CRD42024504417。
■这项荟萃分析旨在找出维生素D水平与TC风险之间的关联。
■根据PubMed，Embase,WebofScience,科克伦,和ClinicalTrials.gov.结果是与对照组相比，TC患者的维生素D水平以及TC患者维生素D缺乏的发生率。效果测量包括标准化平均差(SMD)，均值比(RoM)，和比值比(OR)。进行剂量反应荟萃分析以评估维生素D水平与TC风险之间的相关性。进行亚组分析和荟萃回归以探索异质性的来源。并通过Begg\和Egger\的测试对发表偏倚进行了评估。
■荟萃分析的结果表明，与对照组相比，TC病例中的维生素D水平较低[SMD=-0.25，95％CI：（-0.38，-0.12）；RoM=0.87，95％CI：（0.81，0.94）]，TC病例中的1,25（OH）D水平也低于对照组[SMD=-0.49，95％CI=0.85：0.维生素D缺乏与TC风险增加相关[OR=1.49,95%CI:(1.23,1.80)]。此外,剂量-反应荟萃分析结果显示,25(OH)D水平每降低10ng/ml,TC风险就会增加6%[OR=0.94;95%CI:(0.89,0.99)].
■与对照组相比，TC患者的维生素D水平较低，维生素D缺乏与TC风险增加相关。
■https://www.crd.约克。AC.uk/PROSPERO/display_record。php?RecordID=504417，标识符：CRD42024504417。
