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Abstract：
The relationship between demographic/clinical characteristics, clinical outcomes and the development of hemorrhagic complications in patients with ischemic stroke who underwent reperfusion therapy has not been studied sufficiently. We have aimed to compare genders and age groups in terms of clinical features and outcome; and types of reperfusion treatments and clinical features regarding the development of hemorrhagic complications in patients with ischemic stroke who underwent recombinant tissue plasminogen activator (rtPA) and/or thrombectomy. Patients with acute ischemic stroke undergoing rtPA and/or thrombectomy were divided into six age groups. Parameters including hemorrhagic complications, anticoagulant and antiaggregant use, hyperlipidemia, smoking status, biochemical parameters, and comorbidities were documented. National Institutes of Health Stroke Scale (NIHSS) scores, modified Rankin Score (mRS) and Glasgow Coma Scale scores were recorded. Etiological classification of stroke was done. These parameters were compared in terms of age groups, genders, and hemorrhagic complications. Significant differences were found between age groups concerning hypertension, coronary artery disease, smoking status, and antiaggregant use. Rate of hemorrhagic complications in rtPA group was significantly lower when compared with other treatment groups. Hemorrhagic complications developed mostly in the rtPA+thrombectomy group. Among the patients who developed hemorrhagic complications, NIHSS scores on admission were found to be significantly lower in men than women. Admission, discharge, and 3rd month mRS values in men were significantly lower than those of women. Knowing demographic and clinical features of patients that may have an impact on the clinical course of ischemic stroke managed with reperfusion therapy will be useful in predicting the hemorrhagic complications and clinical outcomes.
摘要：
人口统计学/临床特征之间的关系，对接受再灌注治疗的缺血性卒中患者的临床结局和出血性并发症的发展尚未得到充分研究.我们的目的是比较性别和年龄组的临床特征和结果;以及再灌注治疗的类型和缺血性中风患者出血并发症的发展的临床特征，接受重组组织纤溶酶原激活剂（rtPA）和/或血栓切除术。将接受rtPA和/或血栓切除术的急性缺血性卒中患者分为六个年龄组。参数包括出血性并发症，抗凝剂和抗凝剂的使用，高脂血症,吸烟状况,生化参数，并记录了合并症。美国国立卫生研究院卒中量表(NIHSS)评分,记录改良的Rankin评分（mRS）和格拉斯哥昏迷量表评分。进行了卒中的病因分类。这些参数按年龄组进行了比较，性别,出血性并发症.发现年龄组之间在高血压方面存在显着差异，冠状动脉疾病,吸烟状况,和抗凝集剂的使用。rtPA组出血并发症发生率明显低于其他治疗组。出血并发症主要发生在rtPA+血栓切除组。在出现出血并发症的患者中，发现男性入院时的NIHSS得分明显低于女性。Admission,放电,男性的第3个月mRS值显着低于女性。了解患者的人口统计学和临床特征，这些特征可能会影响再灌注治疗的缺血性中风的临床过程，这将有助于预测出血性并发症和临床结局。
