PDF(Pubmed)
Abstract：
UNASSIGNED: Colorectal cancer (CRC) is a global health concern, and identifying prognostic factors can improve outcomes. Myosteatosis is fat infiltration into muscles and is a potential predictor of the survival of patients with CRC.
UNASSIGNED: This systematic review and meta-analysis aimed to assess the prognostic role of myosteatosis in CRC. PubMed, Embase, and Cochrane CENTRAL were searched up to 1 August 2023, for relevant studies, using combinations of the keywords CRC, myosteatosis, skeletal muscle fat infiltration, and low skeletal muscle radiodensity. Case-control, prospective, and retrospective cohort studies examining the association between myosteatosis and CRC outcomes after curative intent surgery were eligible for inclusion. Primary outcomes were overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS).
UNASSIGNED: A total of 10 studies with a total of 9,203 patients were included. The pooled hazard ratio (HR) for OS (myosteatosis vs. no myosteatosis) was 1.52 [95% confidence interval (CI), 1.38-1.67); for CSS, 1.67 (95% CI, 1.40-1.99); and for DFS, 1.89 (95% CI, 1.35-2.65).
UNASSIGNED: In patients with CRC undergoing curative intent surgery, myosteatosis is associated with worse OS, CSS, and DFS. These findings underscore the importance of evaluating myosteatosis in patients with CRC to improve outcomes.
UNASSIGNED: This systematic review and meta-analysis aimed to assess the prognostic role of myosteatosis in CRC. PubMed, Embase, and Cochrane CENTRAL were searched up to 1 August 2023, for relevant studies, using combinations of the keywords CRC, myosteatosis, skeletal muscle fat infiltration, and low skeletal muscle radiodensity. Case-control, prospective, and retrospective cohort studies examining the association between myosteatosis and CRC outcomes after curative intent surgery were eligible for inclusion. Primary outcomes were overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS).
UNASSIGNED: A total of 10 studies with a total of 9,203 patients were included. The pooled hazard ratio (HR) for OS (myosteatosis vs. no myosteatosis) was 1.52 [95% confidence interval (CI), 1.38-1.67); for CSS, 1.67 (95% CI, 1.40-1.99); and for DFS, 1.89 (95% CI, 1.35-2.65).
UNASSIGNED: In patients with CRC undergoing curative intent surgery, myosteatosis is associated with worse OS, CSS, and DFS. These findings underscore the importance of evaluating myosteatosis in patients with CRC to improve outcomes.
摘要：
■结直肠癌（CRC）是全球健康问题，确定预后因素可以改善预后。肌肉骨化是脂肪渗入肌肉，是CRC患者生存的潜在预测指标。
■本系统综述和荟萃分析旨在评估肌浆病在CRC中的预后作用。PubMed,Embase,和CochraneCENTRAL在2023年8月1日之前进行了搜索，以进行相关研究，使用关键字CRC的组合，肌肉骨化病,骨骼肌脂肪浸润，和低骨骼肌放射密度。病例控制,prospective,和回顾性队列研究符合纳入条件,这些研究包括了治疗性手术后肌骨形成与CRC结局之间的关系.主要结果是总生存期（OS），无病生存率（DFS），癌症特异性生存率（CSS）。
■共纳入10项研究，共9,203名患者。OS的合并风险比(HR)(肌骨形成与无肌肉骨化)为1.52[95%置信区间(CI)，1.38-1.67)；对于CSS，1.67（95%CI，1.40-1.99）；对于DFS，1.89（95%CI，1.35-2.65）。
■在接受根治性手术的CRC患者中，肌肉骨化与OS恶化有关，CSS,和DFS。这些发现强调了评估CRC患者肌骨形成对改善预后的重要性。
■本系统综述和荟萃分析旨在评估肌浆病在CRC中的预后作用。PubMed,Embase,和CochraneCENTRAL在2023年8月1日之前进行了搜索，以进行相关研究，使用关键字CRC的组合，肌肉骨化病,骨骼肌脂肪浸润，和低骨骼肌放射密度。病例控制,prospective,和回顾性队列研究符合纳入条件,这些研究包括了治疗性手术后肌骨形成与CRC结局之间的关系.主要结果是总生存期（OS），无病生存率（DFS），癌症特异性生存率（CSS）。
■共纳入10项研究，共9,203名患者。OS的合并风险比(HR)(肌骨形成与无肌肉骨化)为1.52[95%置信区间(CI)，1.38-1.67)；对于CSS，1.67（95%CI，1.40-1.99）；对于DFS，1.89（95%CI，1.35-2.65）。
■在接受根治性手术的CRC患者中，肌肉骨化与OS恶化有关，CSS,和DFS。这些发现强调了评估CRC患者肌骨形成对改善预后的重要性。
