PDF(Pubmed)
Abstract：
UNASSIGNED: Lactate dehydrogenase (LDH) and albumin (ALB) were found to be significantly correlated with mortality in pulmonary embolism (PE) patients. However, data regarding the LDH/ALB ratio (LAR) in patients with acute PE are scanty. Therefore, the aim of this study was to investigate the association between LAR and the risk of mortality in patients with acute PE.
UNASSIGNED: A retrospective cohort study was conducted on patients with acute PE represented in the Medical Information Mart for Intensive Care IV (MIMIC-IV). A receiver operating characteristic (ROC) curve analysis and calibration curve were used to assess the accuracy of the LAR for predicting mortality in patients with acute PE. We utilized Cox regression analysis to determine adjusted hazard ratios (HR) and 95% confidence interval (CI). Survival curves were used to evaluate a connection between the LAR and prognosis in patients with acute PE.
UNASSIGNED: The study comprised 581 patients, and the 30-day all-cause mortality rate was 7.7%. We observed a higher LAR in the non-survival group compared to the surviving group (21.24 ± 21.22 vs. 8.99 ± 7.86, p < 0.0001). The Kaplan-Meier analysis showed that patients with an elevated LAR had a significantly lower likelihood of surviving the 30-day mortality compared to those with a low LAR. Cox regression analysis showed that LAR (HR = 1.04, 95% CI: 1.03-1.05) might have associations with 30-day mortality in patients with acute PE. This result was supported by sensitivity analyses. According to the results of the ROC curve analysis, the LAR\'s prediction of 30-day mortality in patients with acute PE yielded an area under the ROC curve of 0.73. A calibration curve showed LAR is well calibrated.
UNASSIGNED: Our research suggests LAR monitoring may be promising as a prognostic marker among patients with acute PE.
UNASSIGNED: A retrospective cohort study was conducted on patients with acute PE represented in the Medical Information Mart for Intensive Care IV (MIMIC-IV). A receiver operating characteristic (ROC) curve analysis and calibration curve were used to assess the accuracy of the LAR for predicting mortality in patients with acute PE. We utilized Cox regression analysis to determine adjusted hazard ratios (HR) and 95% confidence interval (CI). Survival curves were used to evaluate a connection between the LAR and prognosis in patients with acute PE.
UNASSIGNED: The study comprised 581 patients, and the 30-day all-cause mortality rate was 7.7%. We observed a higher LAR in the non-survival group compared to the surviving group (21.24 ± 21.22 vs. 8.99 ± 7.86, p < 0.0001). The Kaplan-Meier analysis showed that patients with an elevated LAR had a significantly lower likelihood of surviving the 30-day mortality compared to those with a low LAR. Cox regression analysis showed that LAR (HR = 1.04, 95% CI: 1.03-1.05) might have associations with 30-day mortality in patients with acute PE. This result was supported by sensitivity analyses. According to the results of the ROC curve analysis, the LAR\'s prediction of 30-day mortality in patients with acute PE yielded an area under the ROC curve of 0.73. A calibration curve showed LAR is well calibrated.
UNASSIGNED: Our research suggests LAR monitoring may be promising as a prognostic marker among patients with acute PE.
摘要：
■发现乳酸脱氢酶（LDH）和白蛋白（ALB）与肺栓塞（PE）患者的死亡率显着相关。然而,关于急性PE患者LDH/ALB比值(LAR)的数据很少.因此,本研究的目的是探讨急性PE患者LAR与死亡风险之间的关系.
■对重症监护医学信息集市（MIMIC-IV）中代表的急性PE患者进行了一项回顾性队列研究。受试者工作特征（ROC）曲线分析和校准曲线用于评估LAR预测急性PE患者死亡率的准确性。我们使用Cox回归分析来确定调整后的风险比（HR）和95％置信区间（CI）。生存曲线用于评估急性PE患者LAR与预后之间的联系。
■该研究包括581名患者，30天全因死亡率为7.7%.与存活组相比，我们观察到非存活组的LAR较高（21.24±21.22vs.8.99±7.86，p<0.0001）。Kaplan-Meier分析显示，与LAR低的患者相比，LAR升高的患者存活30天死亡率的可能性明显降低。Cox回归分析显示，LAR（HR=1.04，95％CI：1.03-1.05）可能与急性PE患者30天死亡率相关。这一结果得到了敏感性分析的支持。根据ROC曲线分析结果,LAR预测急性PE患者30日死亡率的ROC曲线下面积为0.73.校准曲线显示LAR被良好校准。
■我们的研究表明，LAR监测作为急性PE患者的预后指标可能是有希望的。
■对重症监护医学信息集市（MIMIC-IV）中代表的急性PE患者进行了一项回顾性队列研究。受试者工作特征（ROC）曲线分析和校准曲线用于评估LAR预测急性PE患者死亡率的准确性。我们使用Cox回归分析来确定调整后的风险比（HR）和95％置信区间（CI）。生存曲线用于评估急性PE患者LAR与预后之间的联系。
■该研究包括581名患者，30天全因死亡率为7.7%.与存活组相比，我们观察到非存活组的LAR较高（21.24±21.22vs.8.99±7.86，p<0.0001）。Kaplan-Meier分析显示，与LAR低的患者相比，LAR升高的患者存活30天死亡率的可能性明显降低。Cox回归分析显示，LAR（HR=1.04，95％CI：1.03-1.05）可能与急性PE患者30天死亡率相关。这一结果得到了敏感性分析的支持。根据ROC曲线分析结果,LAR预测急性PE患者30日死亡率的ROC曲线下面积为0.73.校准曲线显示LAR被良好校准。
■我们的研究表明，LAR监测作为急性PE患者的预后指标可能是有希望的。
