PDF(Pubmed)
Abstract：
Autoimmune diseases (AID) have emerged as prominent contributors to disability and mortality worldwide, characterized by intricate pathogenic mechanisms involving genetic, environmental, and autoimmune factors. In response to this challenge, a growing body of research in recent years has delved into genetic modifications, yielding valuable insights into AID prevention and treatment. Sirtuins (SIRTs) constitute a class of NAD-dependent histone deacetylases that orchestrate deacetylation processes, wielding significant regulatory influence over cellular metabolism, oxidative stress, immune response, apoptosis, and aging through epigenetic modifications. Resveratrol, the pioneering activator of the SIRTs family, and its derivatives have captured global scholarly interest. In the context of AID, these compounds hold promise for therapeutic intervention by modulating the SIRTs pathway, impacting immune cell functionality, suppressing the release of inflammatory mediators, and mitigating tissue damage. This review endeavors to explore the potential of resveratrol and its derivatives in AID treatment, elucidating their mechanisms of action and providing a comprehensive analysis of current research advancements and obstacles. Through a thorough examination of existing literature, our objective is to advocate for the utilization of resveratrol and its derivatives in AID treatment while offering crucial insights for the formulation of innovative therapeutic approaches.
摘要：
自身免疫性疾病（AID）已成为全球残疾和死亡率的主要贡献者。以涉及遗传的复杂致病机制为特征，环境,和自身免疫因素。为了应对这一挑战，近年来，越来越多的研究人员深入研究了遗传修饰，对AID的预防和治疗产生有价值的见解。Sirtuins（SIRTs）构成了一类依赖于NAD的组蛋白脱乙酰酶，它们协调去乙酰化过程，对细胞代谢产生显著的调节作用，氧化应激，免疫反应，凋亡，和衰老通过表观遗传修饰。白藜芦醇,SIRTs家族的先驱激活者，及其衍生物引起了全球的学术兴趣。在AID的背景下，这些化合物有望通过调节SIRTs途径进行治疗干预，影响免疫细胞功能，抑制炎症介质的释放，减轻组织损伤。这篇综述试图探索白藜芦醇及其衍生物在AID治疗中的潜力。阐明其作用机制，并对当前的研究进展和障碍进行全面分析。通过对现有文献的全面审查，我们的目标是倡导在AID治疗中利用白藜芦醇及其衍生物，同时为创新治疗方法的制定提供重要见解。
