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Abstract：
Emerging evidence has illuminated the pivotal role of long noncoding RNAs (lncRNAs) in orchestrating immunological functions and autoimmune responses. In the context of Crohn\'s disease (CD), an array of novel lncRNAs has been identified in the plasma and intestinal tissues of afflicted individuals, suggesting a dualistic influence on the disease progression, either exacerbating or mitigating its course. Current research has demonstrated the involvement of lncRNAs in competitive endogenous RNA, the inflammation process, epithelial barrier function, gut microbiota imbalance, and epigenetic regulation. This review aims to encapsulate the current knowledge on the lncRNA contribution to CD and underscore potential avenues for future research. LncRNAs are increasingly recognized as significant biomarkers and potential therapeutic targets, holding a key position in the pathogenesis of CD. Furthermore, the unique attributes of circulating lncRNAs, such as minimal side effects, combinational therapy potential, and personalized medicine, render them as promising therapeutic tools for individual health management in CD.
摘要：
新兴的证据已经阐明了长链非编码RNA（lncRNA）在协调免疫功能和自身免疫反应中的关键作用。在克罗恩病(CD)的背景下，已在患病个体的血浆和肠组织中鉴定出一系列新的lncRNAs，表明对疾病进展有二元论的影响，加剧或减轻其过程。目前的研究已经证明lncRNAs参与竞争性内源性RNA，炎症过程，上皮屏障功能，肠道微生物群失衡，和表观遗传调控。这篇综述旨在囊括有关lncRNA对CD的贡献的当前知识，并强调未来研究的潜在途径。LncRNAs越来越被认为是重要的生物标志物和潜在的治疗靶点。在CD的发病机制中占有重要地位。此外，循环lncRNAs的独特属性，例如最小的副作用，联合治疗的潜力，和个性化医疗，使它们成为CD中个人健康管理的有前途的治疗工具。
