PDF(Pubmed)
Abstract：
UNASSIGNED: The management of tumor recurrence (TR) and radiation-induced brain injury (RIBI) poses significant challenges, necessitating the development of effective differentiation strategies. In this study, we investigated the potential of amide proton transfer-weighted (APTw) and arterial spin labeling (ASL) imaging for discriminating between TR and RIBI in patients with high-grade glioma (HGG).
UNASSIGNED: A total of 64 HGG patients receiving standard treatment were enrolled in this study. The patients were categorized based on secondary pathology or MRI follow-up results, and the demographic characteristics of each group were presented. The APTw, rAPTw, cerebral blood flow (CBF) and rCBF values were quantified. The differences in various parameters between TR and RIBI were assessed using the independent-samples t-test. The discriminative performance of these MRI parameters in distinguishing between the two conditions was assessed using receiver operating characteristic (ROC) curve analysis. Additionally, the Delong test was employed to further evaluate their discriminatory ability.
UNASSIGNED: The APTw and CBF values of TR were significantly higher compared to RIBI (P < 0.05). APTw MRI demonstrated superior diagnostic efficiency in distinguishing TR from RIBI (area under the curve [AUC]: 0.864; sensitivity: 75.0 %; specificity: 81.8 %) when compared to ASL imaging. The combined utilization of APTw and CBF value further enhanced the AUC to 0.922. The Delong test demonstrated that the combination of APTw and ASL exhibited superior performance in the identification of TR and RIBI, compared to ASL alone (P = 0.048).
UNASSIGNED: APTw exhibited superior diagnostic efficacy compared to ASL in the evaluation of TR and RIBI. Furthermore, the combination of APTw and ASL exhibits greater discriminatory capability and diagnostic performance.
UNASSIGNED: A total of 64 HGG patients receiving standard treatment were enrolled in this study. The patients were categorized based on secondary pathology or MRI follow-up results, and the demographic characteristics of each group were presented. The APTw, rAPTw, cerebral blood flow (CBF) and rCBF values were quantified. The differences in various parameters between TR and RIBI were assessed using the independent-samples t-test. The discriminative performance of these MRI parameters in distinguishing between the two conditions was assessed using receiver operating characteristic (ROC) curve analysis. Additionally, the Delong test was employed to further evaluate their discriminatory ability.
UNASSIGNED: The APTw and CBF values of TR were significantly higher compared to RIBI (P < 0.05). APTw MRI demonstrated superior diagnostic efficiency in distinguishing TR from RIBI (area under the curve [AUC]: 0.864; sensitivity: 75.0 %; specificity: 81.8 %) when compared to ASL imaging. The combined utilization of APTw and CBF value further enhanced the AUC to 0.922. The Delong test demonstrated that the combination of APTw and ASL exhibited superior performance in the identification of TR and RIBI, compared to ASL alone (P = 0.048).
UNASSIGNED: APTw exhibited superior diagnostic efficacy compared to ASL in the evaluation of TR and RIBI. Furthermore, the combination of APTw and ASL exhibits greater discriminatory capability and diagnostic performance.
摘要：
■肿瘤复发（TR）和放射性脑损伤（RIBI）的管理提出了重大挑战，需要制定有效的差异化战略。在这项研究中,我们研究了酰胺质子转移加权(APTw)和动脉自旋标记(ASL)成像在区分高级别胶质瘤(HGG)患者中的TR和RIBI的潜力.
■本研究共纳入64例接受标准治疗的HGG患者。根据继发性病理或MRI随访结果对患者进行分类，并介绍了各组的人口统计学特征。APTw,rAPTw,对脑血流量(CBF)和rCBF值进行定量.使用独立样本t检验评估TR和RIBI之间的各种参数的差异。使用受试者工作特征（ROC）曲线分析评估了这些MRI参数在区分两种情况时的判别性能。此外,Delong检验用于进一步评估其辨别能力。
■TR的APTw和CBF值明显高于RIBI（P<0.05）。与ASL成像相比，APTwMRI在区分TR和RIBI方面表现出更高的诊断效率（曲线下面积[AUC]：0.864；灵敏度：75.0％；特异性：81.8％）。APTw和CBF值的联合利用进一步将AUC提高到0.922。Delong测试表明，APTw和ASL的组合在鉴定TR和RIBI方面表现出优异的性能，与单纯ASL相比(P=0.048)。
■在TR和RIBI的评估中，APTw与ASL相比具有更高的诊断效能。此外，APTw和ASL的组合表现出更强的辨别能力和诊断性能。
■本研究共纳入64例接受标准治疗的HGG患者。根据继发性病理或MRI随访结果对患者进行分类，并介绍了各组的人口统计学特征。APTw,rAPTw,对脑血流量(CBF)和rCBF值进行定量.使用独立样本t检验评估TR和RIBI之间的各种参数的差异。使用受试者工作特征（ROC）曲线分析评估了这些MRI参数在区分两种情况时的判别性能。此外,Delong检验用于进一步评估其辨别能力。
■TR的APTw和CBF值明显高于RIBI（P<0.05）。与ASL成像相比，APTwMRI在区分TR和RIBI方面表现出更高的诊断效率（曲线下面积[AUC]：0.864；灵敏度：75.0％；特异性：81.8％）。APTw和CBF值的联合利用进一步将AUC提高到0.922。Delong测试表明，APTw和ASL的组合在鉴定TR和RIBI方面表现出优异的性能，与单纯ASL相比(P=0.048)。
■在TR和RIBI的评估中，APTw与ASL相比具有更高的诊断效能。此外，APTw和ASL的组合表现出更强的辨别能力和诊断性能。
