PDF(Pubmed)
Abstract：
Cardiotoxicity, the often-overlooked second leading cause of death in cancer patients, has been associated with certain anticancer drugs. These drugs can induce cardiac damage through various pathways, and their adverse effects on the heart are not fully understood. Cardiotoxicity is a major issue in cancer treatment, particularly with chemotherapeutics, because it can cause cardiac dysfunction such as hypotension, heart failure, and even death. Doxorubicin, 5-fluorouracil, and trastuzumab, all of which are very potent anticancer drugs, are known to cause cardiotoxicity. When it comes to lowering cardiotoxicity and alleviating the harmful effects of chemotherapy medications, nanomedicine has the potential to transport therapeutic molecules. Nanotheranostics offers novel options for identifying and treating cardiotoxicity resulting from a wide range of substances, including anticancer medications. Additionally, theranostics platforms such as micellar systems, carbon-based nanomedicine, solid lipid nanoparticles, polymeric nanoparticles, and liposomes can transport chemotherapeutic medications while minimising their cardiotoxicity. The present level of understanding of the molecular and cellular processes that lead to cardiotoxicity in reaction to both traditional chemotherapy and targeted drug delivery systems is summarised in this article. This review delves into nanomedicine and nanotheranostics, with an emphasis on reducing anticancer medication-induced cardiac toxicity. Nanotheranostics provide potential solutions for early diagnosis and tailored therapy of heart injury by combining diagnostic and therapeutic capabilities into nanomedicine.
摘要：
心脏毒性,癌症患者经常被忽视的第二大死亡原因，与某些抗癌药物有关。这些药物可以通过多种途径引起心脏损伤，它们对心脏的不利影响尚未完全了解。心脏毒性是癌症治疗中的一个主要问题。特别是化疗药物，因为它会导致心脏功能障碍，如低血压，心力衰竭,甚至死亡。阿霉素,5-氟尿嘧啶,和曲妥珠单抗,所有这些都是非常有效的抗癌药物，已知会引起心脏毒性。在降低心脏毒性和减轻化疗药物的有害影响方面，纳米药物具有运输治疗分子的潜力。Nanotheranosics为识别和治疗由多种物质引起的心脏毒性提供了新的选择，包括抗癌药物。此外,theranostics平台，如胶束系统，碳基纳米医学，固体脂质纳米粒，聚合物纳米颗粒，和脂质体可以运输化疗药物，同时最大限度地减少其心脏毒性。本文总结了对导致对传统化学疗法和靶向药物递送系统的心脏毒性的分子和细胞过程的理解水平。这篇综述深入研究了纳米医学和纳米治疗学，重点是减少抗癌药物引起的心脏毒性。Nanotheranosics通过将诊断和治疗能力结合到纳米医学中，为心脏损伤的早期诊断和定制治疗提供了潜在的解决方案。
