PDF(Pubmed)
Abstract：
The hook effect is a well-described but clinically underappreciated immunoassay interference, where a falsely lowered result is caused by analyte excess. We describe a situation in which ferritin immunoassay results from a 27-year-old female with immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome were more than 1000 times lower at a reference laboratory than those determined in-house after dilution. This case underscores the importance for clinical care providers to be aware of the impact of the hook effect on ferritin measurements, and to promptly communicate with the laboratory when there are discrepancies between clinical symptoms and test results.
摘要：
钩效应是一种描述良好但临床上未被重视的免疫测定干扰，其中错误降低的结果是由分析物过量引起的。我们描述了一种情况，在参考实验室中，患有免疫效应细胞相关的噬血细胞淋巴组织细胞样综合征的27岁女性的铁蛋白免疫测定结果比稀释后内部确定的结果低1000倍以上。该案例强调了临床护理提供者意识到钩效应对铁蛋白测量的影响的重要性，并在临床症状与检测结果不一致时及时与实验室沟通。
