Abstract：
Porokeratoses are a heterogenous group of autoinflammatory keratinization disorders all characterized by the presence of a cornoid lamella. In addition to gene mutations affecting the mevalonate pathway, environmental factors such as UV radiation, immunosuppression, trauma, and infection are also thought to contribute to porokeratoses. To date, there are no management guidelines or levels of evidence for commonly used pharmacologic and non-pharmacologic treatment options for porokeratoses. Conventional treatment strategies encompass topical and systemic drugs (e.g., salicylic acid, topical glucocorticoids, and retinoids), phototherapy, laser, and surgical interventions. Better insights into the pathogenesis of porokeratoses have paved the way for the development of novel therapeutic approaches, such as topical statins or the use of monoclonal antibodies. This narrative review aims to summarize both conventional and novel treatment options, including their level of evidence, advantages, and disadvantages.
摘要：
角化病是一组异质性的自身炎性角化性疾病，所有这些疾病的特征都是存在角质层。除了影响甲羟戊酸途径的基因突变，环境因素，如紫外线辐射，免疫抑制,创伤,和感染也被认为是导致口癣的原因。迄今为止,目前尚无常用药物和非药物治疗的治疗指南或证据.常规治疗策略包括局部和全身药物(例如，水杨酸,局部糖皮质激素，和类维生素A)，光疗,激光,和手术干预。更好的认识到的发病机制的孔角化病铺平了道路的发展新的治疗方法，例如局部使用他汀类药物或使用单克隆抗体。这篇叙述性综述旨在总结传统和新颖的治疗方案。包括他们的证据水平,优势,和缺点。
