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Abstract：
Breast cancer (BC) is a highly prevalent malignancy worldwide, with complex pathogenesis and treatment challenges. Research reveals that methyltransferase-like 3 (METTL3) is widely involved in the pathogenesis of several tumors through methylation of its target RNAs, and its role and mechanisms in BC are also extensively studied. In this review, we aim to provide a comprehensive interpretation of available studies and elucidate the relationship between METTL3 and BC. This review suggests that high levels of METTL3 are associated with the pathogenesis, poor prognosis, and drug resistance of BC, suggesting METTL3 as a potential diagnostic or prognostic biomarker and therapeutic target. Collectively, this review provides a comprehensive understanding of how METTL3 functions through RNA methylation, which provides a valuable reference for future fundamental studies and clinical applications.
摘要：
乳腺癌（BC）是世界范围内高度流行的恶性肿瘤，具有复杂的发病机制和治疗挑战。研究表明，甲基转移酶样3（METTL3）通过其靶RNA的甲基化而广泛参与多种肿瘤的发病机制。及其在BC中的作用和机制也被广泛研究。在这次审查中,我们旨在对现有研究进行全面解释,并阐明METTL3与BC之间的关系.这篇综述表明，高水平的METTL3与发病机制有关。预后不良,和BC的耐药性，提示METTL3是潜在的诊断或预后生物标志物和治疗靶点。总的来说，这篇综述提供了对METTL3如何通过RNA甲基化发挥作用的全面理解，为今后的基础研究和临床应用提供了有价值的参考。
