MITF 的 O - GlcNAcylation 调节其活性和乳腺癌中 CDK4 / 6 抑制剂的耐药性。
Mesh : Humans Cyclin-Dependent Kinase 4 / metabolism antagonists & inhibitors Breast Neoplasms / metabolism drug therapy genetics pathology Cyclin-Dependent Kinase 6 / metabolism antagonists & inhibitors Microphthalmia-Associated Transcription Factor / metabolism genetics Female Drug Resistance, Neoplasm / drug effects Piperazines / pharmacology Pyridines / pharmacology Cell Line, Tumor N-Acetylglucosaminyltransferases / metabolism antagonists & inhibitors genetics Animals Mice Protein Kinase Inhibitors / pharmacology Xenograft Model Antitumor Assays
来 源:
DOI:10.1038/s41467-024-49875-w
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