Abstract：
BACKGROUND: This study assessed the difference in 3-, 5-, and 10-year relative survival rates (RSRs) for female breast cancer between White and Black patients across the levels of year, tumor stage, age, and marital status at diagnosis. Confounding factors and effect modifiers were considered.
METHODS: Analyses were based on 17 population-based tumor registries in the Surveillance, Epidemiology, and End Results (SEER) Program. Cases were diagnosed in 2000-2017 and followed through 2020.
RESULTS: Three-, 5-, and 10-year female breast cancer RSRs significantly improved for White and Black patients during the years 2000-2020, more so for Blacks than Whites. Three-, 5-, and 10-year estimated annual percent changes in trends were 0.09%, 0.16%, and 0.29% for Whites and 0.36%, 0.49%, and 0.86% for Blacks, respectively. However, a large difference in RSRs for White and Black patients persists, 4.2% for three-year RSRs, 5.7% for five-year RSRs, and 7.5% for 10-year RSRs, after adjusting for year, tumor stage, age, and marital status at diagnosis. The difference in RSRs between White and Black patients differs by tumor stage at diagnosis. For example, higher five-year RSRs in Whites than Blacks were 2.6% for local, 9.3% for regional, 10.4% for distant, and 6.2% for unknown/unstaged tumors at diagnosis.
CONCLUSIONS: Improvement in 3-, 5-, and 10-year female breast cancer RSRs occurred for both White and Black patients, albeit more so for Blacks. Yet the poorer RSRs for Blacks remain large and significant, increasingly so with later staged disease at diagnosis and as we move from 3- to 5- to 10-year RSRs.
METHODS: Analyses were based on 17 population-based tumor registries in the Surveillance, Epidemiology, and End Results (SEER) Program. Cases were diagnosed in 2000-2017 and followed through 2020.
RESULTS: Three-, 5-, and 10-year female breast cancer RSRs significantly improved for White and Black patients during the years 2000-2020, more so for Blacks than Whites. Three-, 5-, and 10-year estimated annual percent changes in trends were 0.09%, 0.16%, and 0.29% for Whites and 0.36%, 0.49%, and 0.86% for Blacks, respectively. However, a large difference in RSRs for White and Black patients persists, 4.2% for three-year RSRs, 5.7% for five-year RSRs, and 7.5% for 10-year RSRs, after adjusting for year, tumor stage, age, and marital status at diagnosis. The difference in RSRs between White and Black patients differs by tumor stage at diagnosis. For example, higher five-year RSRs in Whites than Blacks were 2.6% for local, 9.3% for regional, 10.4% for distant, and 6.2% for unknown/unstaged tumors at diagnosis.
CONCLUSIONS: Improvement in 3-, 5-, and 10-year female breast cancer RSRs occurred for both White and Black patients, albeit more so for Blacks. Yet the poorer RSRs for Blacks remain large and significant, increasingly so with later staged disease at diagnosis and as we move from 3- to 5- to 10-year RSRs.
摘要：
背景：这项研究评估了3-，5-,白人和黑人女性乳腺癌患者的10年相对生存率（RSRs）跨越一年的水平，肿瘤分期,年龄,和诊断时的婚姻状况。考虑了混杂因素和效应改性剂。
方法：分析基于监测中的17个基于人群的肿瘤登记，流行病学,和最终结果（SEER）计划。病例在2000-2017年被诊断出来，并一直持续到2020年。
结果：三个，5-,在2000-2020年期间，白人和黑人患者的10年女性乳腺癌RSR显着改善，黑人比白人更明显。三-，5-,10年估计的年度百分比趋势变化为0.09%，0.16%，白人为0.29%，白人为0.36%，0.49%，黑人为0.86%，分别。然而,白人和黑人患者的RSR存在很大差异，三年RSR的4.2%，5年期RSR为5.7%，10年期RSR为7.5%，经过一年的调整，肿瘤分期,年龄,和诊断时的婚姻状况。在诊断时，白人和黑人患者之间的RSR差异因肿瘤分期而异。例如,白人的五年RSR高于当地黑人的2.6%，区域9.3%，远端10.4%，诊断时未知/未分期的肿瘤为6.2％。
结论：3-，5-,10年女性乳腺癌RSR发生在白人和黑人患者身上，对黑人来说更是如此。然而，黑人较差的RSR仍然很大而且很重要，随着疾病在诊断时的分期以及我们从3年到5年到10年的RSR的进展，这种情况越来越严重。
方法：分析基于监测中的17个基于人群的肿瘤登记，流行病学,和最终结果（SEER）计划。病例在2000-2017年被诊断出来，并一直持续到2020年。
结果：三个，5-,在2000-2020年期间，白人和黑人患者的10年女性乳腺癌RSR显着改善，黑人比白人更明显。三-，5-,10年估计的年度百分比趋势变化为0.09%，0.16%，白人为0.29%，白人为0.36%，0.49%，黑人为0.86%，分别。然而,白人和黑人患者的RSR存在很大差异，三年RSR的4.2%，5年期RSR为5.7%，10年期RSR为7.5%，经过一年的调整，肿瘤分期,年龄,和诊断时的婚姻状况。在诊断时，白人和黑人患者之间的RSR差异因肿瘤分期而异。例如,白人的五年RSR高于当地黑人的2.6%，区域9.3%，远端10.4%，诊断时未知/未分期的肿瘤为6.2％。
结论：3-，5-,10年女性乳腺癌RSR发生在白人和黑人患者身上，对黑人来说更是如此。然而，黑人较差的RSR仍然很大而且很重要，随着疾病在诊断时的分期以及我们从3年到5年到10年的RSR的进展，这种情况越来越严重。
