PDF(Pubmed)
Abstract：
OBJECTIVE: Subjective cognitive decline (SCD) refers to self-reported memory loss despite normal cognitive function and is considered a preclinical stage of Alzheimer\'s disease. This study aimed to examine the mediating effects of depression and Instrumental Activities of Daily Living (IADL) on the association between the scoring of Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB) and Subjective Cognitive Decline Questionnaire (SCD-Q).
METHODS: A sample of 139 community-dwelling older adults aged 65-79 with normal cognitive function completed the SCD-Q, a comprehensive neuropsychological battery, and functional/psychiatric scales. We conducted 1) a correlation analysis between SCD-Q scores and other variables and 2) a path analysis to examine the mediating effects of depression and IADL on the relationship between CDR-SB and SCD-Q.
RESULTS: CDR-SB was found to be indirectly associated with SCD-Q, with depressive symptoms mediating this relationship. However, no direct association was observed between SCD-Q and CDR-SB. Additionally, IADL was not associated with SCD-Q and did not mediate the relationship between CDR-SB and SCD-Q. The model fit was acceptable (minimum discrepancy function by degrees of freedom divided [CMIN/DF]=1.585, root mean square error of approximation [RMSEA]=0.065, comparative fit index [CFI]=0.955, Tucker-Lewis index [TLI]=0.939).
CONCLUSIONS: Our results suggest that SCD-Q is influenced by depressive symptoms, but not by IADL. The role of depressive symptoms as a mediator between CDR-SB and SCD-Q indicates that psychological factors may contribute to the perception of SCD. Therefore, interventions targeting depression may mitigate the concerns associated with SCD and reduce feelings of worse performance compared to others of the same age group.
METHODS: A sample of 139 community-dwelling older adults aged 65-79 with normal cognitive function completed the SCD-Q, a comprehensive neuropsychological battery, and functional/psychiatric scales. We conducted 1) a correlation analysis between SCD-Q scores and other variables and 2) a path analysis to examine the mediating effects of depression and IADL on the relationship between CDR-SB and SCD-Q.
RESULTS: CDR-SB was found to be indirectly associated with SCD-Q, with depressive symptoms mediating this relationship. However, no direct association was observed between SCD-Q and CDR-SB. Additionally, IADL was not associated with SCD-Q and did not mediate the relationship between CDR-SB and SCD-Q. The model fit was acceptable (minimum discrepancy function by degrees of freedom divided [CMIN/DF]=1.585, root mean square error of approximation [RMSEA]=0.065, comparative fit index [CFI]=0.955, Tucker-Lewis index [TLI]=0.939).
CONCLUSIONS: Our results suggest that SCD-Q is influenced by depressive symptoms, but not by IADL. The role of depressive symptoms as a mediator between CDR-SB and SCD-Q indicates that psychological factors may contribute to the perception of SCD. Therefore, interventions targeting depression may mitigate the concerns associated with SCD and reduce feelings of worse performance compared to others of the same age group.
摘要：
目的：主观认知功能下降（SCD）是指尽管认知功能正常，但自我报告的记忆丧失，被认为是阿尔茨海默病的临床前阶段。本研究旨在研究抑郁症和日常生活工具活动（IADL）对临床痴呆评定量表-方框总和（CDR-SB）和主观认知下降问卷（SCD-Q）评分之间的相关性的中介作用。
方法：对139名社区居住的65-79岁认知功能正常的老年人样本完成了SCD-Q，一个全面的神经心理学电池，和功能/精神量表。我们进行了1）SCD-Q得分与其他变量之间的相关性分析，以及2）路径分析，以检查抑郁症和IADL对CDR-SB与SCD-Q之间关系的中介作用。
结果：发现CDR-SB与SCD-Q间接相关，抑郁症状介导了这种关系。然而,未观察到SCD-Q和CDR-SB之间的直接关联.此外,IADL与SCD-Q无关，也不介导CDR-SB与SCD-Q之间的关系。模型拟合是可以接受的（自由度的最小差异函数[CMIN/DF]=1.585，近似均方根误差[RMSEA]=0.065，比较拟合指数[CFI]=0.955，Tucker-Lewis指数[TLI]=0.939）。
结论：我们的结果表明SCD-Q受抑郁症状的影响，但不是由IADL。抑郁症状作为CDR-SB和SCD-Q之间的介质的作用表明心理因素可能有助于SCD的感知。因此,针对抑郁症的干预措施可以减轻与SCD相关的担忧,并减少与同年龄组的其他人相比表现较差的感觉.
方法：对139名社区居住的65-79岁认知功能正常的老年人样本完成了SCD-Q，一个全面的神经心理学电池，和功能/精神量表。我们进行了1）SCD-Q得分与其他变量之间的相关性分析，以及2）路径分析，以检查抑郁症和IADL对CDR-SB与SCD-Q之间关系的中介作用。
结果：发现CDR-SB与SCD-Q间接相关，抑郁症状介导了这种关系。然而,未观察到SCD-Q和CDR-SB之间的直接关联.此外,IADL与SCD-Q无关，也不介导CDR-SB与SCD-Q之间的关系。模型拟合是可以接受的（自由度的最小差异函数[CMIN/DF]=1.585，近似均方根误差[RMSEA]=0.065，比较拟合指数[CFI]=0.955，Tucker-Lewis指数[TLI]=0.939）。
结论：我们的结果表明SCD-Q受抑郁症状的影响，但不是由IADL。抑郁症状作为CDR-SB和SCD-Q之间的介质的作用表明心理因素可能有助于SCD的感知。因此,针对抑郁症的干预措施可以减轻与SCD相关的担忧,并减少与同年龄组的其他人相比表现较差的感觉.
