METHODS: Studies investigating pain sensitisation in OA with a focus on immune cells and fibroblasts were identified using PubMed, Web of Science and SCOPUS.
RESULTS: In this review, we comprehensively assess the evidence that cellular crosstalk between resident immune cells or synovial fibroblasts with joint nociceptors in inflamed OA synovium contributes to peripheral pain sensitisation. Moreover, we explore whether the elucidation of common mechanisms identified in similar joint conditions may inform the development of more effective analgesics specifically targeting OA joint pain.
CONCLUSIONS: The concept of local environment and cellular crosstalk within the inflammatory synovium as a driver of nociceptive joint pain presents a compelling opportunity for future research and therapeutic advancements.
方法:使用PubMed鉴定了以免疫细胞和成纤维细胞为重点的研究,WebofScience和SCOPUS。
结果:在这篇综述中,我们全面评估了炎症OA滑膜中固有免疫细胞或滑膜成纤维细胞与关节伤害感受器之间的细胞串扰导致外周疼痛致敏的证据.此外,我们探讨了在类似关节疾病中确定的常见机制的阐明是否可以为开发更有效的针对OA关节痛的镇痛药提供信息.
结论:作为伤害性关节痛的驱动因素,炎性滑膜内的局部环境和细胞串扰的概念为未来的研究和治疗进展提供了令人信服的机会。