PDF(Pubmed)
Abstract：
The escalating incidence of opioid-related issues among pregnant women in the United States underscores the critical necessity to understand the effects of opioid use and Medication for Opioid Use Disorders (MOUDs) during pregnancy. This research employed a translational rodent model to examine the impact of gestational exposure to buprenorphine (BUP) or morphine on maternal behaviors and offspring well-being. Female rats received BUP or morphine before conception, representing established use, with exposure continuing until postnatal day 2 or discontinued on gestational day 19 to mimic treatment cessation before birth. Maternal behaviors - including care, pup retrieval, and preference - as well as hunting behaviors and brain neurotransmitter levels were assessed. Offspring were evaluated for mortality, weight, length, milk bands, surface righting latency, withdrawal symptoms, and brain neurotransmitter levels. Our results reveal that regardless of exposure length (i.e., continued or discontinued), BUP resulted in reduced maternal care in contrast to morphine-exposed and control dams. Opioid exposure altered brain monoamine levels in the dams and offspring, and was associated with increased neonatal mortality, reduced offspring weight, and elevated withdrawal symptoms compared to controls. These findings underscore BUP\'s potential disruption of maternal care, contributing to increased pup mortality and altered neurodevelopmental outcomes in the offspring. This study calls for more comprehensive research into prenatal BUP exposure effects on the maternal brain and infant development with the aim to mitigate adverse outcomes in humans exposed to opioids during pregnancy.
摘要：
在美国，孕妇中阿片类药物相关问题的发生率不断上升，这突显了了解怀孕期间阿片类药物使用和阿片类药物使用障碍（MOUD）的影响的关键必要性。这项研究采用了一种翻译啮齿动物模型来研究妊娠暴露于丁丙诺啡（BUP）或吗啡对母体行为和后代幸福感的影响。雌性大鼠在受孕前接受BUP或吗啡，代表既定用途，暴露持续到出生后第2天或在妊娠第19天停止，以模拟出生前停止治疗。产妇的行为-包括护理，幼犬检索,和偏好-以及狩猎行为和脑神经递质水平进行了评估。评估后代的死亡率，体重,长度,牛奶带,表面扶正延迟，戒断症状,和大脑神经递质水平。我们的结果表明，无论暴露时间长短(即，继续或终止)，与吗啡暴露和对照大坝相比，BUP导致产妇护理减少。阿片类药物暴露改变了水坝和后代的大脑单胺水平，并与新生儿死亡率增加有关，减少后代的体重，与对照组相比，戒断症状升高。这些发现强调了BUP对产妇保健的潜在干扰，有助于增加幼崽的死亡率和改变后代的神经发育结果。这项研究要求对产前BUP暴露对母体大脑和婴儿发育的影响进行更全面的研究，以减轻怀孕期间暴露于阿片类药物的人类的不良后果。
