Abstract：
Objective. The availability of tissue-mimicking materials (TMMs) for manufacturing high-quality phantoms is crucial for standardization, evaluating novel quantitative approaches, and clinically translating new imaging modalities, such as photoacoustic imaging (PAI). Recently, a gel comprising the copolymer styrene-ethylene/butylene-styrene (SEBS) in mineral oil has shown significant potential as TMM due to its optical and acoustic properties akin to soft tissue. We propose using artists\' oil-based inks dissolved and diluted in balsam turpentine to tune the optical properties.Approach. A TMM was fabricated by mixing a SEBS copolymer and mineral oil, supplemented with additives to tune its optical absorption and scattering properties independently. A systematic investigation of the tuning accuracies and relationships between concentrations of oil-based pigments and optical absorption properties of the TMM across visible and near-infrared wavelengths using collimated transmission spectroscopy was conducted. The photoacoustic spectrum of various oil-based inks was studied to analyze the effect of increasing concentration and depth.Main results. Artists\' oil-based inks dissolved in turpentine proved effective as additives to tune the optical absorption properties of mineral oil SEBS-gel with high accuracy. The TMMs demonstrated long-term stability and suitability for producing phantoms with desired optical absorption properties for PAI studies.Significance. The findings, including tuning of optical absorption and spectral shape, suggest that this TMM facilitates the development of more sophisticated phantoms of arbitrary shapes. This approach holds promise for advancing the development of PAI, including investigation of the spectral coloring effect. In addition, it can potentially aid in the development and clinical translation of ultrasound optical tomography.
摘要：
目标：用于制造高质量体模的组织模拟材料（TMM）的可用性对于标准化至关重要，评估新的定量方法，并在临床上翻译新的成像模式，例如光声成像(PAI)。最近,在矿物油中包含共聚物苯乙烯-乙烯/丁烯-苯乙烯(SEBS)的凝胶由于其类似于软组织的光学和声学性质而显示出作为TMM的显著潜力。我们建议使用艺术家在香脂松节油中溶解和稀释的油基油墨来调整光学特性。
方法：通过混合SEBS共聚物和矿物油来制造TMM，补充添加剂以独立调节其光吸收和散射特性。使用准直透射光谱法对油基颜料的浓度与TMM在可见光和近红外波长范围内的光吸收特性之间的调谐精度和关系进行了系统的研究。研究了各种油基油墨的光声光谱，分析了浓度和深度增加的影响。
结果：艺术家\'溶解在松节油中的油基油墨被证明是有效的添加剂，可以高精度地调节矿物油SEBS凝胶的光吸收特性。TMM证明了长期稳定性和适合于生产具有PAI研究所需光吸收特性的体模。
结论：调查结果，包括调整光吸收和光谱形状，建议此TMM有助于开发更复杂的任意形状的体模。这种方法为推进PAI的发展提供了希望，包括光谱着色效应的调查。此外,它可能有助于超声光学断层扫描的发展和临床转化。
方法：通过混合SEBS共聚物和矿物油来制造TMM，补充添加剂以独立调节其光吸收和散射特性。使用准直透射光谱法对油基颜料的浓度与TMM在可见光和近红外波长范围内的光吸收特性之间的调谐精度和关系进行了系统的研究。研究了各种油基油墨的光声光谱，分析了浓度和深度增加的影响。
结果：艺术家\'溶解在松节油中的油基油墨被证明是有效的添加剂，可以高精度地调节矿物油SEBS凝胶的光吸收特性。TMM证明了长期稳定性和适合于生产具有PAI研究所需光吸收特性的体模。
结论：调查结果，包括调整光吸收和光谱形状，建议此TMM有助于开发更复杂的任意形状的体模。这种方法为推进PAI的发展提供了希望，包括光谱着色效应的调查。此外,它可能有助于超声光学断层扫描的发展和临床转化。
