关键词: 11C-palmitate FDG PCr/ATP cardiac coronary sinus heart failure metabolism

Mesh : Humans Myocardium / metabolism Heart Failure / metabolism Animals Heart Energy Metabolism

来  源:   DOI:10.1016/j.cmet.2024.06.003

Abstract:
The heart is the most metabolically active organ in the human body, and cardiac metabolism has been studied for decades. However, the bulk of studies have focused on animal models. The objective of this review is to summarize specifically what is known about cardiac metabolism in humans. Techniques available to study human cardiac metabolism are first discussed, followed by a review of human cardiac metabolism in health and in heart failure. Mechanistic insights, where available, are reviewed, and the evidence for the contribution of metabolic insufficiency to heart failure, as well as past and current attempts at metabolism-based therapies, is also discussed.
摘要:
心脏是人体代谢最活跃的器官,心脏代谢已经研究了几十年。然而,大部分研究都集中在动物模型上。这篇综述的目的是具体总结人类心脏代谢的已知情况。首先讨论了可用于研究人类心脏代谢的技术,随后回顾了人类心脏代谢在健康和心力衰竭中的作用。机械见解,如果可用,被审查,以及代谢不足导致心力衰竭的证据,以及过去和现在对基于新陈代谢的疗法的尝试,也讨论了。
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