Abstract：
The recently issued ISSCR standards in stem cell research recommend registration of human pluripotent stem cell lines (hPSCs). Registration is critical to establishing stem cell provenance and connecting cell lines to data derived on those lines. In this study, we sought to understand common barriers to registration by conducting interviews with forty-eight Australian stem cell stakeholders, including researchers, clinicians, and industry professionals. Australian stem cell researchers do not routinely register their lines, and only a third of those Australian lines captured by an international registry have fully completed the registration process. Most registered Australian cell lines lack complete information about their ethical provenance or key pluripotency characteristics. Incomplete registration is poorly aligned with the goals of open science on which registries are founded. Users also expressed concerns about the quality of the incomplete information provided to the resource. Registration was considered negatively, for instance as a hurdle or barrier to publication, which impacted on user perceptions of usefulness of registration and lowered the likelihood that they would engage with registries to find resources. Broader adoption of registration by journals, and continued advocacy by stem cell societies, will be important levers for awareness and engagement with registration. Although the Australian community represents a small fraction of potential registry users, the results of this study suggest ways for journals, registries, funders, and the international stem cell community to improve registration compliance.
摘要：
最近发布的干细胞研究中的ISSCR标准推荐人多能干细胞系(hPSC)的注册。注册对于建立干细胞来源和将细胞系与源自这些细胞系的数据连接至关重要。在这项研究中,我们试图通过与48个澳大利亚干细胞利益相关者进行访谈来了解注册的常见障碍，包括研究人员,临床医生,和行业专业人士。澳大利亚干细胞研究人员通常不会注册他们的细胞系，国际注册局捕获的澳大利亚线路中只有三分之一完全完成了注册过程。大多数注册的澳大利亚细胞系缺乏有关其伦理来源或关键多能性特征的完整信息。不完整的注册与注册管理机构建立的开放科学的目标不相称。用户还对提供给资源的不完整信息的质量表示关切。注册被认为是负面的，例如作为出版的障碍或障碍，这影响了用户对注册有用性的看法，并降低了他们与注册管理机构合作寻找资源的可能性。期刊更广泛地采用注册，干细胞协会的持续倡导，将是意识和参与注册的重要杠杆。尽管澳大利亚社区只占潜在注册用户的一小部分，这项研究的结果为期刊提供了方法，登记册，资助者,和国际干细胞界提高注册合规性。
