关键词: Allogeneic hematopoietic stem cell transplantation Environmental inhalation challenge test Hypersensitivity pneumonitis Myelodysplastic syndrome

来  源:   DOI:10.1016/j.resinv.2024.06.007

Abstract:
A 50-year-old man was diagnosed with hypersensitivity pneumonitis caused by the environment of his bar owing to worsening symptoms, laboratory test results, and computed tomography images after an environmental inhalation challenge test. His hypersensitivity pneumonitis exacerbated despite receiving prednisolone 20 mg/day. The patient underwent allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen-matched unrelated donor for myelodysplastic syndrome. No exacerbation of hypersensitivity pneumonitis was observed after HSCT. An environmental inhalation challenge test involving exposure to his bar confirmed the remission of hypersensitivity pneumonitis after HSCT. This case demonstrates that hypersensitivity pneumonitis can be remitted by HSCT.
摘要:
一名50岁的男子因症状恶化而被诊断为由酒吧环境引起的过敏性肺炎,实验室测试结果,和环境吸入挑战测试后的计算机断层扫描图像。尽管接受泼尼松龙20mg/天,但他的过敏性肺炎加剧。患者接受了来自人类白细胞抗原匹配的无关供体的异基因造血干细胞移植(HSCT),以治疗骨髓增生异常综合征。HSCT后未观察到过敏性肺炎的恶化。涉及暴露于他的酒吧的环境吸入攻击测试证实了HSCT后过敏性肺炎的缓解。该病例表明过敏性肺炎可以通过HSCT缓解。
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