Abstract：
The mitochondrial unfolded protein response (UPRmt) is a cytoprotective response in response to cellular stress that is activated in response to mitochondrial stress to maintain intra-protein homeostasis, thereby protecting the cell from a variety of stimuli. The activation of this response has been linked to cardiovascular diseases. Here, we reviewed the current understanding of UPRmt and discussed its specific molecular mechanism, mainly in mammals, as well as addressing its protective role against cardiovascular diseases, so as to provide direction for further research on UPRmt and therapies targeting cardiovascular diseases in the future.
摘要：
线粒体未折叠蛋白反应（UPRmt）是响应于细胞应激的细胞保护反应，其响应于线粒体应激而被激活以维持蛋白内稳态，从而保护细胞免受各种刺激。这种反应的激活与心血管疾病有关。这里,我们回顾了目前对UPRmt的理解，并讨论了其具体的分子机制，主要是哺乳动物，以及解决其对心血管疾病的保护作用，从而为未来针对心血管疾病的UPRmt和疗法的进一步研究提供方向。
