PDF(Pubmed)
Abstract：
The last couple of decades have highlighted the importance of studying hybridization, particularly among primate species, as it allows us to better understand our own evolutionary trajectory. Here, we report on genetic ancestry estimates using dense, full genome data from 881 olive (Papio anubus), yellow (Papio cynocephalus), or olive-yellow crossed captive baboons from the Southwest National Primate Research Center. We calculated global and local ancestry information, imputed low coverage genomes (n = 830) to improve marker quality, and updated the genetic resources of baboons available to assist future studies. We found evidence of historical admixture in some putatively purebred animals and identified errors within the Southwest National Primate Research Center pedigree. We also compared the outputs between two different phasing and imputation pipelines along with two different global ancestry estimation software. There was good agreement between the global ancestry estimation software, with R2 > 0.88, while evidence of phase switch errors increased depending on what phasing and imputation pipeline was used. We also generated updated genetic maps and created a concise set of ancestry informative markers (n = 1,747) to accurately obtain global ancestry estimates.
摘要：
过去的几十年强调了研究杂交的重要性，特别是在灵长类物种中，因为它能让我们更好地了解自己的进化轨迹。这里,我们报告使用密集的遗传祖先估计，来自881Olive（Papioanubus）的全基因组数据，黄色（麻黄），或西南国家灵长类动物研究中心的橄榄黄色交叉圈养的狒狒。我们计算了全球和当地的祖先信息，估算低覆盖基因组(n=830)以提高标记质量，并更新了狒狒的遗传资源，以协助未来的研究。我们在一些假定的纯种动物中发现了历史混合物的证据，并在西南国家灵长类动物研究中心的谱系中发现了错误。我们还比较了两个不同的相位和归集管道以及两个不同的全球祖先估计软件之间的输出。全球血统估计软件之间有很好的一致性，R2>0.88，而相位切换误差的证据根据使用的相位和归因管道而增加。我们还生成了更新的基因图谱，并创建了一套简洁的祖先信息标记（n=1,747），以准确获得全球祖先估计。
