Abstract：
A major mechanism to modulate the biological activities of the androgen receptor (AR) involves a growing number of post-translational modifications (PTMs). In this review we summarise the current knowledge on the structural and functional impact of PTMs that affect this major transcription factor. Next, we discuss the cross-talk between these different PTMs and the presence of clusters of modified residues in the AR protein. Finally, we discuss the implications of these covalent modifications for the aetiology of diseases such as spinal and bulbar muscular atrophy (Kennedy\'s disease) and prostate cancer, and the perspectives for pharmacological intervention.
摘要：
调节雄激素受体（AR）生物学活性的主要机制涉及越来越多的翻译后修饰（PTM）。在这篇综述中，我们总结了影响该主要转录因子的PTM的结构和功能影响的最新知识。接下来,我们讨论了这些不同PTM之间的串扰和AR蛋白中修饰残基簇的存在。最后,我们讨论了这些共价修饰对疾病如脊髓和延髓肌萎缩症（肯尼迪病）和前列腺癌的病因的影响，以及药物干预的前景。
