Abstract：
Motor learning (ML), which plays a fundamental role in growth and physical rehabilitation, involves different stages of learning and memory processes through different brain regions. However, the neural mechanisms that underlie ML are not sufficiently understood. Here, a previously unreported neuronal projection from the dorsal hippocampus (dHPC) to the zona incerta (ZI) involved in the regulation of ML behaviors is identified. Using recombinant adeno-associated virus, the projections to the ZI are surprisingly identified as originating from the dorsal dentate gyrus (DG) and CA1 subregions of the dHPC. Furthermore, projection-specific chemogenetic and optogenetic manipulation reveals that the projections from the dorsal CA1 to the ZI play key roles in the acquisition and consolidation of ML behaviors, whereas the projections from the dorsal DG to the ZI mediate the retrieval/retention of ML behaviors. The results reveal new projections from the dorsal DG and dorsal CA1 to the ZI involved in the regulation of ML and provide insight into the stages over which this regulation occurs.
摘要：
运动学习（ML），在成长和身体康复中起着重要作用，涉及通过不同大脑区域的学习和记忆过程的不同阶段。然而,ML背后的神经机制还没有得到充分的理解。这里,确定了以前未报告的从背侧海马（dHPC）到不透明带（ZI）的神经元投射，涉及ML行为的调节。使用重组腺相关病毒，令人惊讶的是，ZI的投影被鉴定为源自dHPC的背侧齿状回（DG）和CA1子区域。此外，投射特异性化学遗传学和光遗传学操作表明，从背侧CA1到ZI的投射在ML行为的获得和巩固中起关键作用，而从背侧DG到ZI的投影介导了ML行为的检索/保留。结果揭示了从背侧DG和背侧CA1到参与ML调节的ZI的新预测，并提供了对这种调节发生阶段的见解。
