Abstract:
Magnesium-based biodegradable metal bone implants exhibit superior mechanical properties compared to biodegradable polymers for orthopedic and cardiovascular stents. In this study, MgZZC-x (x = 1, 1.2) alloys were screened by in vitro biocompatibility tests in three simulated body fluids under nontoxic conditions. The MgZZC-1 alloys with better biocompatibility were selected to predict the days required for complete degradation. The evolution of degradation products was analyzed, and the mechanism of formation of the product film was inferred. A degradation kinetic model was established to investigate the effect of MEM components on the degradation of the alloys. The results demonstrate that the proteins in MEM can greatly retard the degradation progress by attaching to the surface of MgZZC-1 alloys, which are predicted to degrade completely within 341 days. The carbonate and phosphate buffers were adjusted to pH in MEM solution, delaying the degradation of magnesium alloys. This process in MEM more accurately reflects the actual degradation in the body and is superior to that in Hanks and SBF solutions. This study will promote the application of biodegradable materials in clinical medicine.
摘要:
与用于骨科和心血管支架的可生物降解聚合物相比,基于镁的可生物降解金属骨植入物表现出优异的机械性能。在这项研究中,通过在无毒条件下在三种模拟体液中进行体外生物相容性测试,筛选了MgZZC-x(x=1,1.2)合金。选择具有更好的生物相容性的MgZZC-1合金来预测完全降解所需的天数。对降解产物的演化进行了分析,并对产品膜的形成机理进行了推断。建立了降解动力学模型,研究了MEM组分对合金降解的影响。结果表明,MEM中的蛋白质可以通过附着在MgZZC-1合金表面来极大地延缓降解进程,预计将在341天内完全降解。将碳酸盐和磷酸盐缓冲液在MEM溶液中调节至pH,延缓镁合金的降解。MEM中的此过程更准确地反映了体内的实际降解,并且优于Hanks和SBF解决方案。本研究将促进生物可降解材料在临床医学中的应用。