Mesh : Animals Anti-Bacterial Agents / pharmacology Gram-Negative Bacteria / drug effects Gram-Positive Bacteria / drug effects Microbial Sensitivity Tests Ants / drug effects Complex Mixtures / pharmacology

来  源:   DOI:10.1590/1519-6984.284085

Abstract:
The current study evaluates the antibacterial activity of Camponotus compressus (Hymenoptera: Formicidae) body crude extracts. The increasing antibiotic resistance of bacteria has prompted the world to turn its attention towards insects in the search for new sources of antibacterial compounds. The body crude extract obtained with different solvents were tested against both Gram positive (Staphylococcus aureus, Bacillus subtilis) and Gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae). Standard disc diffusion method was used to perform the activity. The extracts of C. compressus were investigated for their effectiveness against all resistant pathogenic bacteria. Staphylococcus aureus was found to be the most susceptible, exhibiting a high average growth inhibition, while Bacillus subtilis showed a lower average growth inhibition zone. Our findings regarding the inhibitory effect of C. compressus extracts show the presence of a broad-spectrum antibacterial compound. This will be helpful in the search for novel natural antibiotics against robust pathogenic bacterial strains.
摘要:
当前的研究评估了Camponotuscompressus(膜翅目:Formicidae)身体粗提物的抗菌活性。细菌对抗生素的耐药性不断增加,促使世界将注意力转向昆虫,以寻找新的抗菌化合物来源。用不同溶剂获得的身体粗提取物对革兰氏阳性(金黄色葡萄球菌,枯草芽孢杆菌)和革兰氏阴性菌(铜绿假单胞菌,大肠杆菌,肺炎克雷伯菌)。使用标准圆盘扩散方法进行活性。研究了C.compressus的提取物对所有抗性病原菌的有效性。金黄色葡萄球菌被发现是最易感的,表现出较高的平均生长抑制作用,而枯草芽孢杆菌显示出较低的平均生长抑制区。我们关于C.compressus提取物的抑制作用的发现表明存在广谱抗菌化合物。这将有助于寻找新的天然抗生素来对抗强大的致病性细菌菌株。
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