Abstract：
Angucyclines and angucyclinones represent a class of natural compounds that belong to the group of aromatic polyketides. They exhibit a wide array of biological properties, such as antimicrobial, antiviral, and cytotoxic. Their considerable therapeutic potential and diverse scaffolds have attracted many synthetic chemists to devise novel strategies to construct their intricate molecular architecture. Over 300 class members have been isolated from natural sources, mainly from bacterial strains of Streptomyces species. This review highlights recent advancements in their synthesis, such as oxidative cyclization, photooxidation, and metal-catalyzed [4+2]-cycloaddition, which has facilitated the efficient and practical total syntheses of various angucyclines natural products.
摘要：
Angucycline和angucyclones代表一类属于芳香族聚酮的天然化合物。它们表现出广泛的生物学特性，如抗菌剂，抗病毒，和细胞毒性。它们巨大的治疗潜力和多样化的支架吸引了许多合成化学家设计新策略来构建其复杂的分子结构。300多名班级成员已经从自然来源中分离出来，主要来自链霉菌属的细菌菌株。这篇综述强调了他们合成的最新进展，如氧化环化，光氧化，和金属催化的[4+2]-环加成，这促进了各种angucycles天然产物的有效和实用的总合成。
