关键词: MicroED XFELs in situ X-ray diffraction in vivo crystallography macromolecular research micro-crystallization structural biology

Mesh : Crystallization Crystallography, X-Ray / methods Crystallography / methods Macromolecular Substances / chemistry

来  源:   DOI:10.1107/S205225252400513X   PDF(Pubmed)

Abstract:
A series of events underscoring the significant advancements in micro-crystallization and in vivo crystallography were held during the 26th IUCr Congress in Melbourne, positioning microcrystallography as a pivotal field within structural biology. Through collaborative discussions and the sharing of innovative methodologies, these sessions outlined frontier approaches in macromolecular crystallography. This review provides an overview of this rapidly moving field in light of the rich dialogues and forward-thinking proposals explored during the congress workshop and microsymposium. These advances in microcrystallography shed light on the potential to reshape current research paradigms and enhance our comprehension of biological mechanisms at the molecular scale.
摘要:
在墨尔本举行的第26届IUCr大会期间,举行了一系列活动,突显了微晶和体内晶体学的重大进展,将微晶体学定位为结构生物学中的关键领域。通过合作讨论和分享创新方法,这些会议概述了大分子晶体学的前沿方法。根据大会研讨会和微观研讨会期间探讨的丰富对话和前瞻性建议,本审查概述了这一快速发展的领域。微晶体学的这些进展揭示了重塑当前研究范式并增强我们对分子尺度生物机制的理解的潜力。
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