PDF(Pubmed)
Abstract：
Influenza A virus (IAV) is a negative-sense single-stranded RNA virus that causes acute lung injury and acute respiratory distress syndrome, posing a serious threat to both animal and human health. N6-methyladenosine (m6A), a prevalent and abundant post-transcriptional methylation of RNA in eukaryotes, plays a crucial regulatory role in IAV infection by altering viral RNA and cellular transcripts to affect viral infection and the host immune response. This review focuses on the molecular mechanisms underlying m6A modification and its regulatory function in the context of IAV infection and the host immune response. This will provide a better understanding of virus-host interactions and offer insights into potential anti-IAV strategies.
摘要：
甲型流感病毒(IAV)是一种可引起急性肺损伤和急性呼吸窘迫综合征的负义单链RNA病毒,严重威胁动物和人类的健康。N6-甲基腺苷（m6A），在真核生物中普遍存在和丰富的RNA转录后甲基化，通过改变病毒RNA和细胞转录本影响病毒感染和宿主免疫应答,在IAV感染中发挥重要的调节作用。本文综述了m6A修饰的分子机制及其在IAV感染和宿主免疫应答中的调控功能。这将提供对病毒-宿主相互作用的更好理解，并提供对潜在抗IAV策略的见解。
