PDF(Pubmed)
Abstract：
UNASSIGNED: Serum cholinesterase (ChE) levels are considered to reflect nutritional status. Although ChE has been well documented as a prognostic factor for some cancers, no clear consensus on its use for colorectal cancer (CRC) has been reached. The aim of this study was to investigate the relationship between preoperative serum ChE and postoperative long-term prognosis in CRC patients.
UNASSIGNED: A total of 1053 CRC patients who underwent curative surgery were included in this study. The correlations between the preoperative ChE value and overall survival (OS) or cancer-specific survival (CSS) were assessed. By dividing patients into two groups according to their ChE value, OS and CSS were compared between the groups.
UNASSIGNED: Multivariate analysis revealed that the continuous ChE value was a significant predictor of OS (hazard ratio, 0.996; 95% CI, 0.993-0.998; p = 0.002) and CSS (hazard ratio, 0.994; 95% CI, 0.991-0.998; p = 0.001), independent of other variables. The low-ChE (≤234 U/L) group had a significantly poorer prognosis than the high-ChE (>234 U/L) group for both OS (5-year OS for low ChE and high ChE: 79.8% and 93.3%, respectively; p < 0.001) and CSS (5-year CSS for low ChE and high ChE: 84.8% and 95.6%, respectively; p < 0.001).
UNASSIGNED: Lower preoperative serum ChE levels are a predictive factor of poor prognosis for CRC patients. As serum ChE levels can be measured quickly and evaluated easily, ChE could become a useful marker for predicting the postoperative long-term outcomes of CRC patients.
UNASSIGNED: A total of 1053 CRC patients who underwent curative surgery were included in this study. The correlations between the preoperative ChE value and overall survival (OS) or cancer-specific survival (CSS) were assessed. By dividing patients into two groups according to their ChE value, OS and CSS were compared between the groups.
UNASSIGNED: Multivariate analysis revealed that the continuous ChE value was a significant predictor of OS (hazard ratio, 0.996; 95% CI, 0.993-0.998; p = 0.002) and CSS (hazard ratio, 0.994; 95% CI, 0.991-0.998; p = 0.001), independent of other variables. The low-ChE (≤234 U/L) group had a significantly poorer prognosis than the high-ChE (>234 U/L) group for both OS (5-year OS for low ChE and high ChE: 79.8% and 93.3%, respectively; p < 0.001) and CSS (5-year CSS for low ChE and high ChE: 84.8% and 95.6%, respectively; p < 0.001).
UNASSIGNED: Lower preoperative serum ChE levels are a predictive factor of poor prognosis for CRC patients. As serum ChE levels can be measured quickly and evaluated easily, ChE could become a useful marker for predicting the postoperative long-term outcomes of CRC patients.
摘要：
■血清胆碱酯酶(ChE)水平被认为反映了营养状况。尽管ChE已被证明是某些癌症的预后因素，尚未就其用于结直肠癌(CRC)达成明确共识.本研究旨在探讨CRC患者术前血清ChE与术后远期预后的关系。
■本研究共纳入1053例接受治愈性手术的CRC患者。评估术前ChE值与总生存期（OS）或癌症特异性生存期（CSS）之间的相关性。通过根据患者的ChE值将患者分为两组，组间比较OS和CSS。
■多变量分析显示，连续ChE值是OS的重要预测因子(风险比，0.996；95%CI，0.993-0.998；p=0.002）和CSS（风险比，0.994；95%CI，0.991-0.998；p=0.001），独立于其他变量。低ChE(≤234U/L)组的预后均显著差于高ChE(>234U/L)组(低ChE和高ChE的5年OS:79.8%和93.3%,分别为；p<0.001)和CSS(低ChE和高ChE的5年CSS：84.8%和95.6%，分别为；p<0.001)。
■术前血清ChE水平降低是CRC患者预后不良的预测因素。由于血清ChE水平可以快速测量并易于评估，ChE可能成为预测CRC患者术后长期预后的有用标志物。
■本研究共纳入1053例接受治愈性手术的CRC患者。评估术前ChE值与总生存期（OS）或癌症特异性生存期（CSS）之间的相关性。通过根据患者的ChE值将患者分为两组，组间比较OS和CSS。
■多变量分析显示，连续ChE值是OS的重要预测因子(风险比，0.996；95%CI，0.993-0.998；p=0.002）和CSS（风险比，0.994；95%CI，0.991-0.998；p=0.001），独立于其他变量。低ChE(≤234U/L)组的预后均显著差于高ChE(>234U/L)组(低ChE和高ChE的5年OS:79.8%和93.3%,分别为；p<0.001)和CSS(低ChE和高ChE的5年CSS：84.8%和95.6%，分别为；p<0.001)。
■术前血清ChE水平降低是CRC患者预后不良的预测因素。由于血清ChE水平可以快速测量并易于评估，ChE可能成为预测CRC患者术后长期预后的有用标志物。
