PDF(Pubmed)
Abstract：
UNASSIGNED: Elevated intracranial pressure (ICP) is a serious and potentially life-threatening condition, for which clinically useful non-invasive measures have been elusive, in some cases due to their inadequate sensitivity and specificity. Our aim was to evaluate novel non-invasive ophthalmic imaging of selected pathological features seen in elevated ICP, namely peripapillary hyperreflective ovoid mass-like structures (PHOMS), peripapillary wrinkles (PPW) and retinal folds (RF) as potential biomarkers of elevated ICP.
UNASSIGNED: This single-center pilot study included subjects with untreated or incompletely treated high ICP. The retinas of these subjects were evaluated with averaged en-face optical coherence tomography (OCT), OCT retinal cross-sections (OCT B-scans), adaptive optics scanning light ophthalmoscopy (AOSLO), and fundus photos.
UNASSIGNED: Seven subjects were included in the study. 6 subjects with high ICP (5 idiopathic intracranial hypertension, 1 medication induced, 30.8 ± 8.6 years, 75% female, 5 with papilledema) and 1 control (20-25 years) were included. PHOMS, PPW and RF were present in all subjects with papilledema, but neither in the high ICP subject without papilledema nor in the control subject. Averaged en-face OCT scans and AOSLO were more sensitive for PPW and RF than OCT B-scans and commercial fundus photos.
UNASSIGNED: PPW, RF and PHOMS volume have potential as non-invasive biomarkers of ICP. Novel imaging modalities may improve sensitivity. However, lack of automated image acquisition and processing limits current widespread adoption in clinical settings. Further research is needed to validate these structures as biomarkers for elevated ICP and improve clinical utility.
UNASSIGNED: This single-center pilot study included subjects with untreated or incompletely treated high ICP. The retinas of these subjects were evaluated with averaged en-face optical coherence tomography (OCT), OCT retinal cross-sections (OCT B-scans), adaptive optics scanning light ophthalmoscopy (AOSLO), and fundus photos.
UNASSIGNED: Seven subjects were included in the study. 6 subjects with high ICP (5 idiopathic intracranial hypertension, 1 medication induced, 30.8 ± 8.6 years, 75% female, 5 with papilledema) and 1 control (20-25 years) were included. PHOMS, PPW and RF were present in all subjects with papilledema, but neither in the high ICP subject without papilledema nor in the control subject. Averaged en-face OCT scans and AOSLO were more sensitive for PPW and RF than OCT B-scans and commercial fundus photos.
UNASSIGNED: PPW, RF and PHOMS volume have potential as non-invasive biomarkers of ICP. Novel imaging modalities may improve sensitivity. However, lack of automated image acquisition and processing limits current widespread adoption in clinical settings. Further research is needed to validate these structures as biomarkers for elevated ICP and improve clinical utility.
摘要：
■颅内压（ICP）升高是一种严重且可能危及生命的疾病，临床上有用的非侵入性措施难以捉摸，在某些情况下，由于它们的敏感性和特异性不足。我们的目的是评估在升高的ICP中看到的选定病理特征的新型非侵入性眼科成像。即乳头周围超反射卵形团状结构（PHOMS），乳头周围皱纹（PPW）和视网膜皱褶（RF）是ICP升高的潜在生物标志物。
■此单中心试点研究包括未经治疗或未完全治疗的高ICP受试者。使用平均正面光学相干断层扫描（OCT）评估这些受试者的视网膜，OCT视网膜横截面（OCTB扫描），自适应光学扫描光检眼镜（AOSLO），和眼底照片。
■研究中包括7名受试者。6名患有高ICP的受试者（5名特发性颅内高压，1药物诱导，30.8±8.6年，75%女性,包括5例乳头水肿）和1例对照（20-25年）。PHOMS,PPW和RF存在于所有患有乳头水肿的受试者中，但无论是在没有乳头水肿的高ICP受试者中，还是在对照受试者中。平均面OCT扫描和AOSLO对PPW和RF比OCTB扫描和商业眼底照片更敏感。
■PPW，RF和PHOMS体积具有作为ICP的非侵入性生物标志物的潜力。新的成像模式可以提高灵敏度。然而,缺乏自动图像采集和处理限制了目前在临床环境中的广泛采用。需要进一步的研究来验证这些结构作为升高的ICP的生物标志物并提高临床实用性。
■此单中心试点研究包括未经治疗或未完全治疗的高ICP受试者。使用平均正面光学相干断层扫描（OCT）评估这些受试者的视网膜，OCT视网膜横截面（OCTB扫描），自适应光学扫描光检眼镜（AOSLO），和眼底照片。
■研究中包括7名受试者。6名患有高ICP的受试者（5名特发性颅内高压，1药物诱导，30.8±8.6年，75%女性,包括5例乳头水肿）和1例对照（20-25年）。PHOMS,PPW和RF存在于所有患有乳头水肿的受试者中，但无论是在没有乳头水肿的高ICP受试者中，还是在对照受试者中。平均面OCT扫描和AOSLO对PPW和RF比OCTB扫描和商业眼底照片更敏感。
■PPW，RF和PHOMS体积具有作为ICP的非侵入性生物标志物的潜力。新的成像模式可以提高灵敏度。然而,缺乏自动图像采集和处理限制了目前在临床环境中的广泛采用。需要进一步的研究来验证这些结构作为升高的ICP的生物标志物并提高临床实用性。
