PDF(Pubmed)
Abstract：
UNASSIGNED: Coronaviruses (CoVs) belong to the RNA viruses family. The viruses in this family are known to cause mild respiratory disease in humans. The origin of the novel SARS-COV2 virus that caused the coronavirus-19 disease (COVID-19) is the Wuhan city in China from where it disseminated to cause a global pandemic. Although lungs are the predominant target organ for Coronavirus Disease-19 (COVID-19), since its outbreak, the disease is known to affect heart, blood vessels, kidney, intestine, liver and brain. This review aimed to summarize the catastrophic impacts of Coronavirus disease-19 on heart and liver along with its mechanisms of pathogenesis.
UNASSIGNED: The information used in this review was obtained from relevant articles published on PubMed, Google Scholar, Google, WHO website, CDC and other sources. Key searching statements and phrases related to COVID-19 were used to retrieve information. Original research articles, review papers, research letters and case reports were used as a source of information.
UNASSIGNED: Besides causing severe lung injury, COVID-19 has also been reported to affect and cause dysfunction of many other organs. COVID-19 infection can affect people by downregulating membrane-bound active angiotensin-converting enzyme (ACE). People who have deficient ACE2 expression are more vulnerable to COVID-19 infection. The patients\' pre-existing co-morbidities are major risk factors that predispose individuals to severe COVID-19.
UNASSIGNED: The disease severity and its broad spectrum phenotype is a result of combined direct and indirect pathogenic factors. Therefore, protocols that harmonize many therapeutic preferences should be the best alternatives to de-escalate the disease and obviate deaths caused as a result of multiple organ damage and dysfunction induced by the disease.
UNASSIGNED: The information used in this review was obtained from relevant articles published on PubMed, Google Scholar, Google, WHO website, CDC and other sources. Key searching statements and phrases related to COVID-19 were used to retrieve information. Original research articles, review papers, research letters and case reports were used as a source of information.
UNASSIGNED: Besides causing severe lung injury, COVID-19 has also been reported to affect and cause dysfunction of many other organs. COVID-19 infection can affect people by downregulating membrane-bound active angiotensin-converting enzyme (ACE). People who have deficient ACE2 expression are more vulnerable to COVID-19 infection. The patients\' pre-existing co-morbidities are major risk factors that predispose individuals to severe COVID-19.
UNASSIGNED: The disease severity and its broad spectrum phenotype is a result of combined direct and indirect pathogenic factors. Therefore, protocols that harmonize many therapeutic preferences should be the best alternatives to de-escalate the disease and obviate deaths caused as a result of multiple organ damage and dysfunction induced by the disease.
摘要：
■冠状病毒(CoV)属于RNA病毒家族。已知该家族中的病毒在人类中引起轻度呼吸道疾病。导致冠状病毒-19疾病（COVID-19）的新型SARS-COV2病毒的起源是中国武汉市，它从那里传播以引起全球大流行。尽管肺部是19型冠状病毒病(COVID-19)的主要靶器官，自从它爆发以来，已知这种疾病会影响心脏，血管,肾,肠,肝脏和大脑。本文旨在总结冠状病毒病-19对心脏和肝脏的灾难性影响及其发病机制。
■本评论中使用的信息来自PubMed上发表的相关文章，谷歌学者，Google,世卫组织网站,CDC和其他来源。使用与COVID-19相关的关键搜索语句和短语来检索信息。原创研究文章,审查文件，研究信函和病例报告被用作信息来源。
■除了造成严重的肺损伤，据报道，COVID-19还影响并导致许多其他器官的功能障碍。COVID-19感染可通过下调膜结合活性血管紧张素转换酶（ACE）来影响人。ACE2表达不足的人更容易感染COVID-19。患者预先存在的合并症是使个体易患严重COVID-19的主要危险因素。
■疾病的严重程度及其广谱表型是直接和间接致病因素综合作用的结果。因此,协调许多治疗偏好的方案应该是使疾病降级并避免由于疾病引起的多器官损伤和功能障碍而导致的死亡的最佳替代方案。
■本评论中使用的信息来自PubMed上发表的相关文章，谷歌学者，Google,世卫组织网站,CDC和其他来源。使用与COVID-19相关的关键搜索语句和短语来检索信息。原创研究文章,审查文件，研究信函和病例报告被用作信息来源。
■除了造成严重的肺损伤，据报道，COVID-19还影响并导致许多其他器官的功能障碍。COVID-19感染可通过下调膜结合活性血管紧张素转换酶（ACE）来影响人。ACE2表达不足的人更容易感染COVID-19。患者预先存在的合并症是使个体易患严重COVID-19的主要危险因素。
■疾病的严重程度及其广谱表型是直接和间接致病因素综合作用的结果。因此,协调许多治疗偏好的方案应该是使疾病降级并避免由于疾病引起的多器官损伤和功能障碍而导致的死亡的最佳替代方案。
