PDF(Pubmed)
Abstract：
UNASSIGNED: Exposure to environmental pollutants early in life has been associated with increased prevalence and severity of depression in adolescents; however, the neurobiological mechanisms underlying this association are not well understood. In the current longitudinal study, we investigated whether pollution burden in early adolescence (9-13 years) was associated with altered brain activation and connectivity during implicit emotion regulation and changes in depressive symptoms across adolescence.
UNASSIGNED: One hundred forty-five participants (n = 87 female; 9-13 years) provided residential addresses, from which we determined their relative pollution burden at the census tract level, and performed an implicit affective regulation task in the scanner. Participants also completed questionnaires assessing depressive symptoms at 3 time points, each approximately 2 years apart, from which we calculated within-person slopes of depressive symptoms. We conducted whole-brain activation and connectivity analyses to examine whether pollution burden was associated with alterations in brain function during implicit emotion regulation of positively and negatively valenced stimuli and how these effects were related to slopes of depressive symptoms across adolescence.
UNASSIGNED: Greater pollution burden was associated with greater bilateral medial prefrontal cortex activation and stronger bilateral medial prefrontal cortex connectivity with regions within the default mode network (e.g., temporoparietal junction, posterior cingulate cortex, precuneus) during implicit regulation of negative emotions, which was associated with greater increases in depressive symptoms across adolescence in those exposed to higher pollution burden.
UNASSIGNED: Adolescents living in communities characterized by greater pollution burden showed altered default mode network functioning during implicit regulation of negative emotions that was associated with increases in depressive symptoms across adolescence.
Exposure to environmental pollution is related to increased risk for depression in youth; however, the neurobiological mechanisms underlying this association are unknown. We found that adolescents living in neighborhoods with greater census tract–level pollution burden had stronger functional connectivity between the medial prefrontal cortex and regions within the default mode network during implicit regulation of negative emotions, which in turn was associated with greater increases in depressive symptoms across adolescence in these pollution-exposed youths.
UNASSIGNED: One hundred forty-five participants (n = 87 female; 9-13 years) provided residential addresses, from which we determined their relative pollution burden at the census tract level, and performed an implicit affective regulation task in the scanner. Participants also completed questionnaires assessing depressive symptoms at 3 time points, each approximately 2 years apart, from which we calculated within-person slopes of depressive symptoms. We conducted whole-brain activation and connectivity analyses to examine whether pollution burden was associated with alterations in brain function during implicit emotion regulation of positively and negatively valenced stimuli and how these effects were related to slopes of depressive symptoms across adolescence.
UNASSIGNED: Greater pollution burden was associated with greater bilateral medial prefrontal cortex activation and stronger bilateral medial prefrontal cortex connectivity with regions within the default mode network (e.g., temporoparietal junction, posterior cingulate cortex, precuneus) during implicit regulation of negative emotions, which was associated with greater increases in depressive symptoms across adolescence in those exposed to higher pollution burden.
UNASSIGNED: Adolescents living in communities characterized by greater pollution burden showed altered default mode network functioning during implicit regulation of negative emotions that was associated with increases in depressive symptoms across adolescence.
Exposure to environmental pollution is related to increased risk for depression in youth; however, the neurobiological mechanisms underlying this association are unknown. We found that adolescents living in neighborhoods with greater census tract–level pollution burden had stronger functional connectivity between the medial prefrontal cortex and regions within the default mode network during implicit regulation of negative emotions, which in turn was associated with greater increases in depressive symptoms across adolescence in these pollution-exposed youths.
摘要：
生命早期接触环境污染物与青少年抑郁症患病率和严重程度的增加有关；然而，这种关联的神经生物学机制尚不清楚.在目前的纵向研究中，我们调查了青春期早期(9~13岁)的污染负担是否与内隐情绪调节期间的脑激活和脑连接改变以及整个青春期抑郁症状的变化有关.
■一百四十五名参与者（n=87名女性；9-13岁）提供了住址，从中我们确定了它们在人口普查区的相对污染负担，并在扫描仪中执行隐式情感调节任务。参与者还完成了3个时间点的抑郁症状评估问卷，每隔大约2年，从中我们计算了人内抑郁症状的斜率。我们进行了全脑激活和连通性分析，以检查在积极和消极刺激的内隐情绪调节期间，污染负担是否与脑功能改变有关，以及这些影响如何与青春期抑郁症状的斜率有关。
■更大的污染负担与更大的双侧内侧前额叶皮层激活和更强的双侧内侧前额叶皮层与默认模式网络内区域的连通性有关（例如，颞顶交界处，后扣带皮质，precuneus)在负面情绪的内隐调节期间，在暴露于较高污染负担的人群中，这与青春期抑郁症状的增加有关。
生活在污染负担较大的社区中的青少年在负面情绪的内隐调节过程中表现出改变的默认模式网络功能，这与青春期抑郁症状的增加有关。
暴露于环境污染与青少年患抑郁症的风险增加有关；然而，这种关联的神经生物学机制尚不清楚.我们发现，在负面情绪的内隐调节过程中，生活在人口普查道污染负担较高的社区中的青少年在内侧前额叶皮层和默认模式网络内的区域之间具有更强的功能连通性，这反过来又与这些暴露于污染的年轻人的青春期抑郁症状增加有关。
■一百四十五名参与者（n=87名女性；9-13岁）提供了住址，从中我们确定了它们在人口普查区的相对污染负担，并在扫描仪中执行隐式情感调节任务。参与者还完成了3个时间点的抑郁症状评估问卷，每隔大约2年，从中我们计算了人内抑郁症状的斜率。我们进行了全脑激活和连通性分析，以检查在积极和消极刺激的内隐情绪调节期间，污染负担是否与脑功能改变有关，以及这些影响如何与青春期抑郁症状的斜率有关。
■更大的污染负担与更大的双侧内侧前额叶皮层激活和更强的双侧内侧前额叶皮层与默认模式网络内区域的连通性有关（例如，颞顶交界处，后扣带皮质，precuneus)在负面情绪的内隐调节期间，在暴露于较高污染负担的人群中，这与青春期抑郁症状的增加有关。
生活在污染负担较大的社区中的青少年在负面情绪的内隐调节过程中表现出改变的默认模式网络功能，这与青春期抑郁症状的增加有关。
暴露于环境污染与青少年患抑郁症的风险增加有关；然而，这种关联的神经生物学机制尚不清楚.我们发现，在负面情绪的内隐调节过程中，生活在人口普查道污染负担较高的社区中的青少年在内侧前额叶皮层和默认模式网络内的区域之间具有更强的功能连通性，这反过来又与这些暴露于污染的年轻人的青春期抑郁症状增加有关。
