PDF(Pubmed)
Abstract：
Subfertility, a prevalent and emotionally taxing condition affecting couples worldwide, has garnered increasing attention in reproductive health. While its etiology remains multifaceted, emerging research has explored the role of serum homocysteine levels and nutrient deficiencies in influencing subfertility. This comprehensive review synthesizes current knowledge, beginning with an introduction to subfertility and the significance of investigating serum homocysteine levels. It proceeds to elucidate the role of nutrient deficiencies, particularly folate and vitamin B12, in homocysteine metabolism and examines existing research linking homocysteine to subfertility. The review explores potential mechanisms underlying this relationship, addressing the variability in study findings and their contributing factors. Implications for clinical practice, including assessing serum homocysteine levels, nutritional interventions, and personalized medicine, are discussed. Moreover, the review underscores the importance of ongoing research. It offers a call to action for advancing our understanding of subfertility and improving the lives of individuals and couples navigating reproduction challenges.
摘要：
不育症,影响全世界夫妻的普遍和情感负担的状况，在生殖健康方面引起了越来越多的关注。虽然其病因仍然是多方面的,新兴研究探索了血清同型半胱氨酸水平和营养缺乏在影响低生育中的作用。这篇全面的综述综合了当前的知识，首先介绍了低生育力和调查血清同型半胱氨酸水平的意义。它继续阐明营养缺乏的作用，特别是叶酸和维生素B12，在高半胱氨酸代谢，并检查了现有的研究，将高半胱氨酸与不育联系起来。这篇综述探讨了这种关系背后的潜在机制，解决研究结果的变异性及其影响因素。对临床实践的影响，包括评估血清同型半胱氨酸水平，营养干预,和个性化医疗，正在讨论。此外，该综述强调了正在进行的研究的重要性。它呼吁采取行动，以增进我们对低生育力的理解，并改善应对生殖挑战的个人和夫妇的生活。
