PDF(Pubmed)
Abstract：
BACKGROUND: The constellation of pre and perinatal predictors are introduced as predictor for autism spectrum disorders (ASD), however, the information about the direction and strength of these predictors are lacking in Western, Iran. The current study aimed to determine the pre and perinatal predictors of ASD among children in this region.
METHODS: This case-control study was conducted in Hamadan, Western Iran during January to March 2022. The study included 100 children with ASD who referred to the autism center as case group. Hundred children without ASD from registration system of health service centers were selected as control group and were matched (1:1) to cases by age and place of residency. A structured questionnaire about pre and perinatal predictors of ASD was developed by an expert panel. The questionnaire was administered by interviewing the mothers of children.
RESULTS: Boy gender (OR: 3.51, 95% CI: 1.74-7.10, p-value < 0.001), small for gestational age (SGA) (3.92, 1.64-9.39, 0.002), maternal diabetes (3.51, 1.03-24.95, 0.04) and family history of mental disorders (3.64, 1.18-11.27, 0.04) were identified as significant predictors in a multivariable analysis.
CONCLUSIONS: Our study emphasizes on the importance of screening and monitoring for ASD in the boys, those with history of SGA, from mothers with history of diabetes and with family history of mental disorders. Proposing the replication of findings emphasizes the necessity of conducting studies with larger sample sizes.
METHODS: This case-control study was conducted in Hamadan, Western Iran during January to March 2022. The study included 100 children with ASD who referred to the autism center as case group. Hundred children without ASD from registration system of health service centers were selected as control group and were matched (1:1) to cases by age and place of residency. A structured questionnaire about pre and perinatal predictors of ASD was developed by an expert panel. The questionnaire was administered by interviewing the mothers of children.
RESULTS: Boy gender (OR: 3.51, 95% CI: 1.74-7.10, p-value < 0.001), small for gestational age (SGA) (3.92, 1.64-9.39, 0.002), maternal diabetes (3.51, 1.03-24.95, 0.04) and family history of mental disorders (3.64, 1.18-11.27, 0.04) were identified as significant predictors in a multivariable analysis.
CONCLUSIONS: Our study emphasizes on the importance of screening and monitoring for ASD in the boys, those with history of SGA, from mothers with history of diabetes and with family history of mental disorders. Proposing the replication of findings emphasizes the necessity of conducting studies with larger sample sizes.
摘要：
背景：引入了产前和围产期预测因子的星座作为自闭症谱系障碍（ASD）的预测因子，然而,西方缺乏关于这些预测因子的方向和强度的信息，伊朗。本研究旨在确定该地区儿童ASD的产前和围产期预测因素。
方法：这项病例对照研究在哈马丹进行，伊朗西部，2022年1月至3月。该研究包括100名自闭症儿童，他们将自闭症中心称为病例组。选择来自卫生服务中心注册系统的100名无ASD儿童作为对照组，并按年龄和居住地与病例相匹配（1：1）。专家小组制定了有关ASD的产前和围产期预测因素的结构化问卷。问卷是通过采访孩子的母亲来进行的。
结果：男孩性别（OR：3.51，95％CI：1.74-7.10，p值<0.001），小于胎龄（SGA）（3.92，1.64-9.39，0.002），在多变量分析中,母体糖尿病(3.51,1.03~24.95,0.04)和精神障碍家族史(3.64,1.18~11.27,0.04)被确定为显著的预测因子.
结论：我们的研究强调了筛查和监测男孩ASD的重要性，那些有SGA历史的人，来自有糖尿病史和精神障碍家族史的母亲。提出复制发现强调了进行更大样本量研究的必要性。
方法：这项病例对照研究在哈马丹进行，伊朗西部，2022年1月至3月。该研究包括100名自闭症儿童，他们将自闭症中心称为病例组。选择来自卫生服务中心注册系统的100名无ASD儿童作为对照组，并按年龄和居住地与病例相匹配（1：1）。专家小组制定了有关ASD的产前和围产期预测因素的结构化问卷。问卷是通过采访孩子的母亲来进行的。
结果：男孩性别（OR：3.51，95％CI：1.74-7.10，p值<0.001），小于胎龄（SGA）（3.92，1.64-9.39，0.002），在多变量分析中,母体糖尿病(3.51,1.03~24.95,0.04)和精神障碍家族史(3.64,1.18~11.27,0.04)被确定为显著的预测因子.
结论：我们的研究强调了筛查和监测男孩ASD的重要性，那些有SGA历史的人，来自有糖尿病史和精神障碍家族史的母亲。提出复制发现强调了进行更大样本量研究的必要性。
