PDF(Pubmed)
Abstract：
BACKGROUND: Plasma lipid concentrations in patients with anorexia nervosa (AN) seem to be altered.
METHODS: We conducted a naturalistic study with 75 adult female patients with AN and 26 healthy female controls (HC). We measured plasma lipid profile, sex hormones and used self-report questionnaires at admission and discharge.
RESULTS: Total cholesterol (median (IQR): 4.9 (1.2)) and triglycerides (TG) (1.2 (0.8)) were elevated in AN at admission (BMI 15.3 (3.4)) compared with HC (4.3 (0.7), p = 0.003 and 0.9 (0.3), p = 0.006) and remained elevated at discharge (BMI 18.9 (2.9)) after weight restoration treatment. Estradiol (0.05 (0.1)) and testosterone (0.5 (0.7)) were lower in AN compared with HC (0.3 (0.3), p = < 0.001 and 0.8 (0.5), p = 0.03) and remained low at discharge. There was no change in eating disorder symptoms. Depression symptoms decreased (33 (17) to 30.5 (19), (p = 0.007)). Regression analyses showed that illness duration was a predictor of TG, age was a predictor of total cholesterol and LDL, while educational attainment predicted LDL and TG.
CONCLUSIONS: Lipid concentrations remained elevated following weight restoration treatment, suggesting an underlying, premorbid dysregulation in the lipid metabolism in AN that persists following weight restoration. Elevated lipid concentrations may be present prior to illness onset in AN.
METHODS: III: Evidence obtained from well-designed cohort or case-control analytic studies.
Fat is essential for the human body. Too much fat in the blood can be a sign of underlying illness including heart disease. This study investigated how plasma lipids (fats) are affected in individuals with anorexia nervosa (AN). We included 75 adult female individuals with AN and 26 healthy female controls, and measured lipids, sex hormones, and used questionnaires upon admission and discharge from treatment. We found that low-weight individuals with AN had higher lipids than the healthy controls, and these lipids remained elevated after weight restoration treatment. Additionally, individuals with AN had lower levels of sex hormones (estradiol and testosterone) at their low weight, and they stayed low even after weight restoration treatment. Eating disorder symptoms remained unchanged, but depression symptoms decreased during treatment. In conclusion, the study suggests that individuals with AN have changes in their lipid metabolism, which persists even after weight restoration treatment. We don’t know the reason behind these elevated lipids, and therefore, this should be investigated further in future study.
METHODS: We conducted a naturalistic study with 75 adult female patients with AN and 26 healthy female controls (HC). We measured plasma lipid profile, sex hormones and used self-report questionnaires at admission and discharge.
RESULTS: Total cholesterol (median (IQR): 4.9 (1.2)) and triglycerides (TG) (1.2 (0.8)) were elevated in AN at admission (BMI 15.3 (3.4)) compared with HC (4.3 (0.7), p = 0.003 and 0.9 (0.3), p = 0.006) and remained elevated at discharge (BMI 18.9 (2.9)) after weight restoration treatment. Estradiol (0.05 (0.1)) and testosterone (0.5 (0.7)) were lower in AN compared with HC (0.3 (0.3), p = < 0.001 and 0.8 (0.5), p = 0.03) and remained low at discharge. There was no change in eating disorder symptoms. Depression symptoms decreased (33 (17) to 30.5 (19), (p = 0.007)). Regression analyses showed that illness duration was a predictor of TG, age was a predictor of total cholesterol and LDL, while educational attainment predicted LDL and TG.
CONCLUSIONS: Lipid concentrations remained elevated following weight restoration treatment, suggesting an underlying, premorbid dysregulation in the lipid metabolism in AN that persists following weight restoration. Elevated lipid concentrations may be present prior to illness onset in AN.
METHODS: III: Evidence obtained from well-designed cohort or case-control analytic studies.
Fat is essential for the human body. Too much fat in the blood can be a sign of underlying illness including heart disease. This study investigated how plasma lipids (fats) are affected in individuals with anorexia nervosa (AN). We included 75 adult female individuals with AN and 26 healthy female controls, and measured lipids, sex hormones, and used questionnaires upon admission and discharge from treatment. We found that low-weight individuals with AN had higher lipids than the healthy controls, and these lipids remained elevated after weight restoration treatment. Additionally, individuals with AN had lower levels of sex hormones (estradiol and testosterone) at their low weight, and they stayed low even after weight restoration treatment. Eating disorder symptoms remained unchanged, but depression symptoms decreased during treatment. In conclusion, the study suggests that individuals with AN have changes in their lipid metabolism, which persists even after weight restoration treatment. We don’t know the reason behind these elevated lipids, and therefore, this should be investigated further in future study.
摘要：
背景：神经性厌食症（AN）患者的血浆脂质浓度似乎发生了改变。
方法：我们对75名患有AN的成年女性患者和26名健康女性对照（HC）进行了一项自然研究。我们测量了血浆脂质分布，性激素并在入院和出院时使用自我报告问卷。
结果：总胆固醇（中位数（IQR）：4.9（1.2））和甘油三酯（TG）（1.2（0.8））在入院时升高（BMI15.3（3.4））与HC（4.3（0.7）相比，p=0.003和0.9(0.3)，p=0.006），并在体重恢复治疗后出院时保持升高（BMI18.9（2.9））。与HC相比，AN中的雌二醇（0.05（0.1））和睾丸激素（0.5（0.7））较低（0.3（0.3），p=<0.001和0.8(0.5)，p=0.03），并在放电时保持较低。进食障碍症状没有变化。抑郁症状减少（33（17）至30.5（19），（p=0.007））。回归分析显示病程是TG的预测因子,年龄是总胆固醇和低密度脂蛋白的预测因子，而受教育程度预测LDL和TG。
结论：体重恢复治疗后，脂质浓度仍然升高，暗示了一个潜在的，体重恢复后持续存在的AN中脂质代谢异常。在AN疾病发作之前可能存在脂质浓度升高。
方法：III：从精心设计的队列或病例对照分析研究中获得的证据。
脂肪是人体必需的。血液中脂肪过多可能是包括心脏病在内的潜在疾病的征兆。这项研究调查了神经性厌食症（AN）患者的血浆脂质（脂肪）如何受到影响。我们纳入了75名患有AN的成年女性个体和26名健康女性对照，测量脂质，性激素,并在入院和出院时使用问卷。我们发现患有AN的低体重个体的血脂高于健康对照组，这些脂质在体重恢复治疗后仍然升高。此外,患有AN的个体在低体重时性激素（雌二醇和睾丸激素）水平较低，即使在体重恢复治疗后，它们也保持较低。进食障碍症状保持不变，但抑郁症状在治疗期间有所减轻。总之,这项研究表明，患有AN的个体的脂质代谢发生变化，即使在体重恢复治疗后仍然存在。我们不知道这些脂质升高背后的原因，因此,这应该在未来的研究中进一步研究。
方法：我们对75名患有AN的成年女性患者和26名健康女性对照（HC）进行了一项自然研究。我们测量了血浆脂质分布，性激素并在入院和出院时使用自我报告问卷。
结果：总胆固醇（中位数（IQR）：4.9（1.2））和甘油三酯（TG）（1.2（0.8））在入院时升高（BMI15.3（3.4））与HC（4.3（0.7）相比，p=0.003和0.9(0.3)，p=0.006），并在体重恢复治疗后出院时保持升高（BMI18.9（2.9））。与HC相比，AN中的雌二醇（0.05（0.1））和睾丸激素（0.5（0.7））较低（0.3（0.3），p=<0.001和0.8(0.5)，p=0.03），并在放电时保持较低。进食障碍症状没有变化。抑郁症状减少（33（17）至30.5（19），（p=0.007））。回归分析显示病程是TG的预测因子,年龄是总胆固醇和低密度脂蛋白的预测因子，而受教育程度预测LDL和TG。
结论：体重恢复治疗后，脂质浓度仍然升高，暗示了一个潜在的，体重恢复后持续存在的AN中脂质代谢异常。在AN疾病发作之前可能存在脂质浓度升高。
方法：III：从精心设计的队列或病例对照分析研究中获得的证据。
脂肪是人体必需的。血液中脂肪过多可能是包括心脏病在内的潜在疾病的征兆。这项研究调查了神经性厌食症（AN）患者的血浆脂质（脂肪）如何受到影响。我们纳入了75名患有AN的成年女性个体和26名健康女性对照，测量脂质，性激素,并在入院和出院时使用问卷。我们发现患有AN的低体重个体的血脂高于健康对照组，这些脂质在体重恢复治疗后仍然升高。此外,患有AN的个体在低体重时性激素（雌二醇和睾丸激素）水平较低，即使在体重恢复治疗后，它们也保持较低。进食障碍症状保持不变，但抑郁症状在治疗期间有所减轻。总之,这项研究表明，患有AN的个体的脂质代谢发生变化，即使在体重恢复治疗后仍然存在。我们不知道这些脂质升高背后的原因，因此,这应该在未来的研究中进一步研究。
