Abstract：
The vasculature of the retina is exposed to systemic and local factors that have the capacity to induce several retinal vascular diseases, each of which may lead to vision loss. Prostaglandin signaling has arisen as a potential therapeutic target for several of these diseases due to the diverse manners in which these lipid mediators may affect retinal blood vessel function. Previous reports and clinical practices have investigated cyclooxygenase (COX) inhibition by nonsteroidal anti-inflammatory drugs (NSAIDs) to address retinal diseases with varying degrees of success; however, targeting individual prostanoids or their distinct receptors affords more signaling specificity and poses strong potential for therapeutic development. This review offers a comprehensive view of prostanoid signaling involved in five key retinal vascular diseases: retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, retinal occlusive diseases, and uveitis. Mechanistic and clinical studies of these lipid mediators provide an outlook for therapeutic development with the potential to reduce vision loss in each of these conditions.
摘要：
视网膜的脉管系统暴露于全身和局部因素，这些因素有能力诱发几种视网膜血管疾病，每一种都可能导致视力丧失。由于这些脂质介质可能影响视网膜血管功能的不同方式，前列腺素信号传导已成为这些疾病中几种的潜在治疗靶标。以前的报道和临床实践已经研究了非甾体抗炎药（NSAIDs）对环氧合酶（COX）的抑制作用，以解决视网膜疾病，并取得了不同程度的成功；然而，靶向单个前列腺素类或其不同的受体提供了更多的信号特异性，并为治疗开发提供了强大的潜力。这篇综述提供了涉及五个关键视网膜血管疾病的前列腺素类信号的全面视图：早产儿视网膜病变，糖尿病视网膜病变，年龄相关性黄斑变性,视网膜闭塞性疾病，还有葡萄膜炎.这些脂质介质的机制和临床研究为治疗开发提供了前景，具有在每种情况下减少视力丧失的潜力。
