Abstract：
OBJECTIVE: To determine whether there are quantitative changes in macular, choriocapillary, and peripapillary microvascular structures using optical coherence tomography angiography (OCTA) due to the presence of lupus nephritis (LN) in patients with systemic lupus erythematosus (SLE) and to investigate the correlation between these quantitative values and disease duration.
METHODS: Fifty -five patients followed up in the rheumatology clinic with an SLE diagnosis were evaluated. As the control group, 61 eyes of 61 age- and gender-matched healthy individuals were included. The patients with SLE were further divided into two groups: those with LN (29 eyes) and those without LN (26 eyes). Macular, choriocapillary, and peripapillary microvascular structures were quantitatively analyzed with OCTA and compared between the three study groups. A correlation analysis of the measured quantitative values and disease duration was also performed.
RESULTS: In macular microvascular (MMV) analysis, the vessel densities (VDs) of the superficial capillary plexus (SCP) decreased in both SLE groups, while those of the deep capillary plexus (DCP) decreased only in the SLE group with LN. The foveal density significantly decreased in the SLE group with LN compared to the control group, there were no significant differences in terms of the radial peripapillary capillary VDs or the choriocapillaris flow area. Disease duration was not correlated with any of the quantitative parameters measured by OCTA in either SLE group.
CONCLUSIONS: Identifying differences in retinal microvascular circulation in SLE patients with kidney damage helps predict possible nephropathy and therefore guides the treatment process of this patient.
METHODS: Fifty -five patients followed up in the rheumatology clinic with an SLE diagnosis were evaluated. As the control group, 61 eyes of 61 age- and gender-matched healthy individuals were included. The patients with SLE were further divided into two groups: those with LN (29 eyes) and those without LN (26 eyes). Macular, choriocapillary, and peripapillary microvascular structures were quantitatively analyzed with OCTA and compared between the three study groups. A correlation analysis of the measured quantitative values and disease duration was also performed.
RESULTS: In macular microvascular (MMV) analysis, the vessel densities (VDs) of the superficial capillary plexus (SCP) decreased in both SLE groups, while those of the deep capillary plexus (DCP) decreased only in the SLE group with LN. The foveal density significantly decreased in the SLE group with LN compared to the control group, there were no significant differences in terms of the radial peripapillary capillary VDs or the choriocapillaris flow area. Disease duration was not correlated with any of the quantitative parameters measured by OCTA in either SLE group.
CONCLUSIONS: Identifying differences in retinal microvascular circulation in SLE patients with kidney damage helps predict possible nephropathy and therefore guides the treatment process of this patient.
摘要：
目的：为了确定黄斑是否有定量变化，脉络膜毛细管，由于系统性红斑狼疮（SLE）患者存在狼疮性肾炎（LN），使用光学相干断层扫描血管造影（OCTA）和乳头状周围微血管结构，并研究这些定量值与疾病持续时间之间的相关性。
方法：评估了在风湿病诊所随访诊断为SLE的55例患者。作为对照组,包括61例年龄和性别匹配的健康个体的61只眼。将SLE患者进一步分为两组：LN组（29只眼）和无LN组（26只眼）。黄斑,脉络膜毛细管，用OCTA对3个研究组的乳头周围微血管结构进行定量分析和比较。还对测量的定量值和疾病持续时间进行了相关性分析。
结果：在黄斑微血管（MMV）分析中，SLE两组浅表毛细血管丛（SCP）的血管密度（VD）均降低，而深毛细血管丛（DCP）的下降仅在患有LN的SLE组中。与对照组相比，SLE伴LN组的中央凹密度显着降低，放射状乳头周围毛细血管VDs或脉络膜毛细血管流动面积没有显着差异。在任一SLE组中，疾病持续时间与OCTA测量的任何定量参数均不相关。
结论：确定SLE肾损害患者视网膜微血管循环的差异有助于预测可能的肾病，从而指导该患者的治疗过程。
方法：评估了在风湿病诊所随访诊断为SLE的55例患者。作为对照组,包括61例年龄和性别匹配的健康个体的61只眼。将SLE患者进一步分为两组：LN组（29只眼）和无LN组（26只眼）。黄斑,脉络膜毛细管，用OCTA对3个研究组的乳头周围微血管结构进行定量分析和比较。还对测量的定量值和疾病持续时间进行了相关性分析。
结果：在黄斑微血管（MMV）分析中，SLE两组浅表毛细血管丛（SCP）的血管密度（VD）均降低，而深毛细血管丛（DCP）的下降仅在患有LN的SLE组中。与对照组相比，SLE伴LN组的中央凹密度显着降低，放射状乳头周围毛细血管VDs或脉络膜毛细血管流动面积没有显着差异。在任一SLE组中，疾病持续时间与OCTA测量的任何定量参数均不相关。
结论：确定SLE肾损害患者视网膜微血管循环的差异有助于预测可能的肾病，从而指导该患者的治疗过程。
