Abstract：
The spread of the SARS-CoV-2 virus has had an unprecedented impact, both by posing a serious risk to human health and by amplifying the burden on the global economy. The rapid identification of the SARS-CoV-2 virus has been crucial to preventing and controlling the spread of SARS-CoV-2 infections. In this study, we propose a multilayered plasmonic nanotrap (MPNT) device for the rapid identification of single particles of SARS-CoV-2 virus in ultra-high sensitivity by surface-enhanced Raman scattering (SERS). The MPNT device is composed of arrays of concentric cylindrical cavities with Ag/SiO2/Ag multilayers deposited on the top and at the bottom. By varying the diameter of the cylinders and the thickness of the multilayers, the resonant optical absorption and local electric field were optimized. The SERS enhancement factors of the proposed device are of the order of 108, which enable the rapid identification of SARS-CoV-2 N protein in concentrations as low as 1.25 × 10-15－12.5 × 10-15 g mL-1 within 1 min. The developed MPNT SERS device provides a label-free and rapid detection platform for SARS-CoV-2 virus. The general nature of the device makes it equally suitable to detect other infectious viruses.
摘要：
SARS-CoV-2病毒的传播产生了前所未有的影响,既对人类健康构成严重威胁，又加大了全球经济的负担。SARS-CoV-2病毒的快速鉴定对于预防和控制SARS-CoV-2感染的传播至关重要。在这项研究中,我们提出了一种多层等离子体纳米阱（MPNT）装置，用于通过表面增强拉曼散射（SERS）以超高灵敏度快速鉴定SARS-CoV-2病毒的单个颗粒。MPNT器件由同心圆柱形腔阵列组成,其中Ag/SiO2/Ag多层沉积在顶部和底部。通过改变圆柱体的直径和多层的厚度，对共振光吸收和局部电场进行了优化。该装置的SERS增强因子约为108，可在1分钟内快速鉴定浓度低至1.25×10-15-12.5×10-15gmL-1的SARS-CoV-2N蛋白。所开发的MPNTSERS设备为SARS-CoV-2病毒提供了无标记快速检测平台。该装置的一般性质使其同样适用于检测其他感染性病毒。
