Abstract：
OBJECTIVE: We conducted a systematic review to assess the scope and effectiveness of interventions to improve human papilloma virus (HPV) vaccination in Africa from 2006 to 2021.
METHODS: Systematic review.
METHODS: Four databases (Medline, Embase, CINAHL and PsycINFO) were searched for articles published between 2006 and 2021. Articles were screened and included based on eligibility criteria using DistillerSR (Version 2.35). Data were extracted and reported using a narrative synthesis. A quality assessment was also conducted for each study using validated quality appraisal tools.
RESULTS: Out of 7603 articles identified by a systematic search, 18 articles met the inclusion criteria. Included studies comprised impact evaluation and cross-sectional studies published between 2012 and 2021 and conducted in eight African countries namely: Nigeria, Cameroon, South Africa, Kenya, Tanzania, Zambia, Mali, and Malawi. Study quality ranged from high to low quality. Interventions comprised fifteen educational and three multicomponent interventions. Out of thirteen impact evaluation studies (all educational interventions), twelve studies were effective in increasing HPV vaccine uptake and/or improving participants\' knowledge, attitudes, and perceptions about the vaccine. Across five cross-sectional studies (two educational and three multicomponent interventions), HPV vaccine uptake rates ranged from 34% to 93.3%, with a consensus on safety and effectiveness in 67.9%-90.3% of participants post-intervention.
CONCLUSIONS: Educational and multicomponent interventions have been implemented to improve HPV vaccination in Africa. While educational interventions have proven effective at improving HPV vaccine uptake, a more diverse range of interventions with robust impact evaluation study designs are needed to strengthen the available evidence and improve vaccine uptake.
METHODS: Systematic review.
METHODS: Four databases (Medline, Embase, CINAHL and PsycINFO) were searched for articles published between 2006 and 2021. Articles were screened and included based on eligibility criteria using DistillerSR (Version 2.35). Data were extracted and reported using a narrative synthesis. A quality assessment was also conducted for each study using validated quality appraisal tools.
RESULTS: Out of 7603 articles identified by a systematic search, 18 articles met the inclusion criteria. Included studies comprised impact evaluation and cross-sectional studies published between 2012 and 2021 and conducted in eight African countries namely: Nigeria, Cameroon, South Africa, Kenya, Tanzania, Zambia, Mali, and Malawi. Study quality ranged from high to low quality. Interventions comprised fifteen educational and three multicomponent interventions. Out of thirteen impact evaluation studies (all educational interventions), twelve studies were effective in increasing HPV vaccine uptake and/or improving participants\' knowledge, attitudes, and perceptions about the vaccine. Across five cross-sectional studies (two educational and three multicomponent interventions), HPV vaccine uptake rates ranged from 34% to 93.3%, with a consensus on safety and effectiveness in 67.9%-90.3% of participants post-intervention.
CONCLUSIONS: Educational and multicomponent interventions have been implemented to improve HPV vaccination in Africa. While educational interventions have proven effective at improving HPV vaccine uptake, a more diverse range of interventions with robust impact evaluation study designs are needed to strengthen the available evidence and improve vaccine uptake.
摘要：
目的：我们进行了系统评价，以评估2006年至2021年在非洲改善人乳头瘤病毒（HPV）疫苗接种的干预措施的范围和有效性。
方法：系统评价。
方法：四个数据库(Medline，Embase,搜索了CINAHL和PsycINFO）在2006年至2021年之间发表的文章。使用DistillerSR（2.35版）基于资格标准筛选并纳入文章。使用叙述性综合提取并报告数据。还使用经过验证的质量评估工具对每个研究进行质量评估。
结果：在通过系统搜索确定的7603篇文章中，18条符合纳入标准。纳入的研究包括2012年至2021年发表的影响评估和横断面研究，在八个非洲国家进行，即：尼日利亚，喀麦隆,南非,肯尼亚,坦桑尼亚,赞比亚，马里,和马拉维。研究质量从高到低质量不等。干预措施包括15项教育干预措施和3项多组分干预措施。在13项影响评估研究(所有教育干预措施)中，12项研究有效增加HPV疫苗的摄取和/或提高参与者的知识，态度，以及对疫苗的看法。在五项横断面研究(两项教育和三项多成分干预)中，HPV疫苗的摄取率从34%到93.3%不等，67.9%-90.3%的参与者在干预后对安全性和有效性达成共识。
结论：已经在非洲实施了教育和多组分干预措施以改善HPV疫苗接种。虽然教育干预已被证明可有效提高HPV疫苗的摄取，我们需要更多样化的干预措施以及稳健的影响评估研究设计,以加强现有证据并提高疫苗的接种.
方法：系统评价。
方法：四个数据库(Medline，Embase,搜索了CINAHL和PsycINFO）在2006年至2021年之间发表的文章。使用DistillerSR（2.35版）基于资格标准筛选并纳入文章。使用叙述性综合提取并报告数据。还使用经过验证的质量评估工具对每个研究进行质量评估。
结果：在通过系统搜索确定的7603篇文章中，18条符合纳入标准。纳入的研究包括2012年至2021年发表的影响评估和横断面研究，在八个非洲国家进行，即：尼日利亚，喀麦隆,南非,肯尼亚,坦桑尼亚,赞比亚，马里,和马拉维。研究质量从高到低质量不等。干预措施包括15项教育干预措施和3项多组分干预措施。在13项影响评估研究(所有教育干预措施)中，12项研究有效增加HPV疫苗的摄取和/或提高参与者的知识，态度，以及对疫苗的看法。在五项横断面研究(两项教育和三项多成分干预)中，HPV疫苗的摄取率从34%到93.3%不等，67.9%-90.3%的参与者在干预后对安全性和有效性达成共识。
结论：已经在非洲实施了教育和多组分干预措施以改善HPV疫苗接种。虽然教育干预已被证明可有效提高HPV疫苗的摄取，我们需要更多样化的干预措施以及稳健的影响评估研究设计,以加强现有证据并提高疫苗的接种.
